Implications of Look AHEAD for clinical trials and clinical practice

for The Look AHEAD Research Group

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1183-1191
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Type 2 Diabetes Mellitus
Clinical Trials
Health
Life Style
Weight Loss
Randomized Controlled Trials
Control Groups
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Implications of Look AHEAD for clinical trials and clinical practice. / for The Look AHEAD Research Group.

In: Diabetes, Obesity and Metabolism, Vol. 16, No. 12, 01.12.2014, p. 1183-1191.

Research output: Contribution to journalReview article

for The Look AHEAD Research Group. / Implications of Look AHEAD for clinical trials and clinical practice. In: Diabetes, Obesity and Metabolism. 2014 ; Vol. 16, No. 12. pp. 1183-1191.
@article{b7266a62ef5742f4980501b7379d8672,
title = "Implications of Look AHEAD for clinical trials and clinical practice",
abstract = "Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.",
author = "{for The Look AHEAD Research Group} and Wing, {Rena R.} and Paula Bolin and Brancati, {Frederick L.} and Bray, {George A.} and Clark, {Jeanne M.} and Mace Coday and Crow, {Richard S.} and Curtis, {Jeffrey M.} and Egan, {Caitlin M.} and Espeland, {Mark A.} and Mary Evans and Foreyt, {John P.} and Siran Ghazarian and Mathilda Coday and Barbara Harrison and Hazuda, {Helen P.} and Hill, {James O.} and Horton, {Edward S.} and Hubbard, {Van S.} and Jakicic, {John M.} and Jeffery, {Robert W.} and Johnson, {Karen C.} and Kahn, {Steven E.} and Kitabchi, {Abbas E.} and Knowler, {William C.} and Lewis, {Cora E.} and Barbara, {Maschak Carey} and Montez, {Maria G.} and Anne Murillo and Karen Johnson and Jennifer Patricio and Anne Peters and Xavier, {Pi Sunyer} and Henry Pownall and David Reboussin and Regensteiner, {Judith G.} and Rickman, {Amy D.} and Ryan, {Donna H.} and Monika Safford and Wadden, {Thomas A.} and Wagenknecht, {Lynne E.} and West, {Delia S.} and Williamson, {David F.} and Yanovski, {Susan Z.} and L. Brancati and Lee Swartzc and Jeanne Charleston and Lawrence Cheskin and Kerry Stewart and Ebenezer Nyenwe",
year = "2014",
month = "12",
day = "1",
doi = "10.1111/dom.12318",
language = "English (US)",
volume = "16",
pages = "1183--1191",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Implications of Look AHEAD for clinical trials and clinical practice

AU - for The Look AHEAD Research Group

AU - Wing, Rena R.

AU - Bolin, Paula

AU - Brancati, Frederick L.

AU - Bray, George A.

AU - Clark, Jeanne M.

AU - Coday, Mace

AU - Crow, Richard S.

AU - Curtis, Jeffrey M.

AU - Egan, Caitlin M.

AU - Espeland, Mark A.

AU - Evans, Mary

AU - Foreyt, John P.

AU - Ghazarian, Siran

AU - Coday, Mathilda

AU - Harrison, Barbara

AU - Hazuda, Helen P.

AU - Hill, James O.

AU - Horton, Edward S.

AU - Hubbard, Van S.

AU - Jakicic, John M.

AU - Jeffery, Robert W.

AU - Johnson, Karen C.

AU - Kahn, Steven E.

AU - Kitabchi, Abbas E.

AU - Knowler, William C.

AU - Lewis, Cora E.

AU - Barbara, Maschak Carey

AU - Montez, Maria G.

AU - Murillo, Anne

AU - Johnson, Karen

AU - Patricio, Jennifer

AU - Peters, Anne

AU - Xavier, Pi Sunyer

AU - Pownall, Henry

AU - Reboussin, David

AU - Regensteiner, Judith G.

AU - Rickman, Amy D.

AU - Ryan, Donna H.

AU - Safford, Monika

AU - Wadden, Thomas A.

AU - Wagenknecht, Lynne E.

AU - West, Delia S.

AU - Williamson, David F.

AU - Yanovski, Susan Z.

AU - Brancati, L.

AU - Swartzc, Lee

AU - Charleston, Jeanne

AU - Cheskin, Lawrence

AU - Stewart, Kerry

AU - Nyenwe, Ebenezer

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

AB - Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84920381368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920381368&partnerID=8YFLogxK

U2 - 10.1111/dom.12318

DO - 10.1111/dom.12318

M3 - Review article

VL - 16

SP - 1183

EP - 1191

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 12

ER -