Importance of β2 adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics

John J. Lima, Mohamad H.N. Mohamed, Timothy H. Self, Louis V. Eberle, Julie A. Johnson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To determine whether race and gender affect β2 receptor-stimulated bronchodilation, we quantified FEV1 and plasma concentrations of albuterol at various times following the oral administration of a single 8-mg dose of albuterol in 15 black and 15 white male and female asthmatics. No important racial or gender differences in albuterol-evoked FEV1 or percent-predicted FEV1 were evident, although females tended to be more sensitive compared to males. Pharmacodynamic (PD) models were fitted to data in 19 patients (63%); FEV1 was too erratic to fit in three, and a clockwise hysteresis in the FEV1 vs. albuterol concentration relationship was observed in eight asthmatics. Mean ± SD baseline (E0), maximal FEV1 (E(max)) and C50 were: 3.18 + 1.031, 4.00 ± 1.121, 7.84 ± 10.2 μg/l, respectively. β2 receptor genotype was determined in 16 patients. All Arg 16 homozygotes exhibited proportional FEV1 response vs. plasma albuterol concentration relationships, and thus were fitted by PD models. All those having a poor FEV1 vs. albuterol concentration relationship carried the Gly 16 allele. We conclude that receptor genotype, but not race or gender, is an important determinant of albuterol pharmacodynamics. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalPulmonary Pharmacology and Therapeutics
Volume13
Issue number3
DOIs
StatePublished - Jan 1 2000

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Albuterol
Adrenergic Receptors
Genotype
Pharmacodynamics
Plasmas
Homozygote
Oral Administration
Hysteresis
Alleles

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Importance of β2 adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics. / Lima, John J.; Mohamed, Mohamad H.N.; Self, Timothy H.; Eberle, Louis V.; Johnson, Julie A.

In: Pulmonary Pharmacology and Therapeutics, Vol. 13, No. 3, 01.01.2000, p. 127-134.

Research output: Contribution to journalArticle

Lima, John J. ; Mohamed, Mohamad H.N. ; Self, Timothy H. ; Eberle, Louis V. ; Johnson, Julie A. / Importance of β2 adrenergic receptor genotype, gender and race on albuterol-evoked bronchodilation in asthmatics. In: Pulmonary Pharmacology and Therapeutics. 2000 ; Vol. 13, No. 3. pp. 127-134.
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