Improved Total Synthesis and Structure-Activity Relationship of Arenastatin A, A Potent Cytotoxic Spongean Depsipeptide

Motomasa Kobayashi, Weiqi Wang, Naoki Ohyabu, Michio Kurosu, Isao Kitagawa

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

An efficient asymmetric synthesis of a cyclic depsipeptide arenastatin A (1) is described. 1, isolated from the marine sponge Dysidea arenaria, exhibited extremely potent cytotoxicity with IC50 of 5 pg/ml for KB cells, and in this context the structure-activity relationship among several stereoisomers of 1 and allied compounds has also been examined.

Original languageEnglish (US)
Pages (from-to)1598-1600
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume43
Issue number9
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Dysidea
Depsipeptides
KB Cells
Stereoisomerism
Porifera
Structure-Activity Relationship
Cytotoxicity
Inhibitory Concentration 50
arenastatin A

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Improved Total Synthesis and Structure-Activity Relationship of Arenastatin A, A Potent Cytotoxic Spongean Depsipeptide. / Kobayashi, Motomasa; Wang, Weiqi; Ohyabu, Naoki; Kurosu, Michio; Kitagawa, Isao.

In: Chemical and Pharmaceutical Bulletin, Vol. 43, No. 9, 01.01.1995, p. 1598-1600.

Research output: Contribution to journalArticle

Kobayashi, Motomasa ; Wang, Weiqi ; Ohyabu, Naoki ; Kurosu, Michio ; Kitagawa, Isao. / Improved Total Synthesis and Structure-Activity Relationship of Arenastatin A, A Potent Cytotoxic Spongean Depsipeptide. In: Chemical and Pharmaceutical Bulletin. 1995 ; Vol. 43, No. 9. pp. 1598-1600.
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