In silico mapping of polymorphic miRNA-mRNA interactions in autoimmune thyroid diseases

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are important regulators of gene expression and translation. The genetic variants altering miRNA targets have been associated with many diseases. Here we systematically mapped the human genetic polymorphisms that may affect miRNA-mRNA interactions in the autoimmune thyroid disease (AITD) pathway. We also mapped the polymorphic miRNA target sites in the genes that have been linked to AITDs or other thyroid-related diseases/phenotypes in genome-wide association studies (GWAS). These genetic polymorphisms may potentially contribute to the pathogenesis of AITDs and other thyroid diseases. The polymorphic miRNA-mRNA interactions we mapped in the AITD pathway and the GWAS-informed thyroid disease loci may provide insights into the possible miRNA-mediated molecular mechanisms through which genetic variants assert their influences on thyroid diseases and phenotypes.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalAutoimmunity
Volume47
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

Thyroid Diseases
MicroRNAs
Computer Simulation
Autoimmune Diseases
Messenger RNA
Genome-Wide Association Study
Genetic Polymorphisms
Phenotype
Medical Genetics
Regulator Genes
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

In silico mapping of polymorphic miRNA-mRNA interactions in autoimmune thyroid diseases. / Cui, Yan.

In: Autoimmunity, Vol. 47, No. 5, 01.01.2014, p. 327-333.

Research output: Contribution to journalArticle

@article{3cba0d637d234307ad7472193d305aaa,
title = "In silico mapping of polymorphic miRNA-mRNA interactions in autoimmune thyroid diseases",
abstract = "MicroRNAs (miRNAs) are important regulators of gene expression and translation. The genetic variants altering miRNA targets have been associated with many diseases. Here we systematically mapped the human genetic polymorphisms that may affect miRNA-mRNA interactions in the autoimmune thyroid disease (AITD) pathway. We also mapped the polymorphic miRNA target sites in the genes that have been linked to AITDs or other thyroid-related diseases/phenotypes in genome-wide association studies (GWAS). These genetic polymorphisms may potentially contribute to the pathogenesis of AITDs and other thyroid diseases. The polymorphic miRNA-mRNA interactions we mapped in the AITD pathway and the GWAS-informed thyroid disease loci may provide insights into the possible miRNA-mediated molecular mechanisms through which genetic variants assert their influences on thyroid diseases and phenotypes.",
author = "Yan Cui",
year = "2014",
month = "1",
day = "1",
doi = "10.3109/08916934.2014.893575",
language = "English (US)",
volume = "47",
pages = "327--333",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - In silico mapping of polymorphic miRNA-mRNA interactions in autoimmune thyroid diseases

AU - Cui, Yan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - MicroRNAs (miRNAs) are important regulators of gene expression and translation. The genetic variants altering miRNA targets have been associated with many diseases. Here we systematically mapped the human genetic polymorphisms that may affect miRNA-mRNA interactions in the autoimmune thyroid disease (AITD) pathway. We also mapped the polymorphic miRNA target sites in the genes that have been linked to AITDs or other thyroid-related diseases/phenotypes in genome-wide association studies (GWAS). These genetic polymorphisms may potentially contribute to the pathogenesis of AITDs and other thyroid diseases. The polymorphic miRNA-mRNA interactions we mapped in the AITD pathway and the GWAS-informed thyroid disease loci may provide insights into the possible miRNA-mediated molecular mechanisms through which genetic variants assert their influences on thyroid diseases and phenotypes.

AB - MicroRNAs (miRNAs) are important regulators of gene expression and translation. The genetic variants altering miRNA targets have been associated with many diseases. Here we systematically mapped the human genetic polymorphisms that may affect miRNA-mRNA interactions in the autoimmune thyroid disease (AITD) pathway. We also mapped the polymorphic miRNA target sites in the genes that have been linked to AITDs or other thyroid-related diseases/phenotypes in genome-wide association studies (GWAS). These genetic polymorphisms may potentially contribute to the pathogenesis of AITDs and other thyroid diseases. The polymorphic miRNA-mRNA interactions we mapped in the AITD pathway and the GWAS-informed thyroid disease loci may provide insights into the possible miRNA-mediated molecular mechanisms through which genetic variants assert their influences on thyroid diseases and phenotypes.

UR - http://www.scopus.com/inward/record.url?scp=84904426571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904426571&partnerID=8YFLogxK

U2 - 10.3109/08916934.2014.893575

DO - 10.3109/08916934.2014.893575

M3 - Article

VL - 47

SP - 327

EP - 333

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 5

ER -