In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia

Ghulam N. Dhabaan, Sazaly AbuBakar, Mahmoud Shorman, Hamimah Hassan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The in vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75% of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5% showed intermediate resistance with MIC ranging between 0.032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40% and 60%, respectively, with a significantly lower MIC range of 0.5-4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalJournal of Chemotherapy
Volume24
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Acinetobacter baumannii
Malaysia
Teaching Hospitals
Microbial Sensitivity Tests
Anti-Bacterial Agents
Infection Control
Growth
tigecycline
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia. / Dhabaan, Ghulam N.; AbuBakar, Sazaly; Shorman, Mahmoud; Hassan, Hamimah.

In: Journal of Chemotherapy, Vol. 24, No. 2, 01.04.2012, p. 87-92.

Research output: Contribution to journalArticle

@article{4e291f00979a42789c94476f25f4a77c,
title = "In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia",
abstract = "The in vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75{\%} of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5{\%} showed intermediate resistance with MIC ranging between 0.032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40{\%} and 60{\%}, respectively, with a significantly lower MIC range of 0.5-4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.",
author = "Dhabaan, {Ghulam N.} and Sazaly AbuBakar and Mahmoud Shorman and Hamimah Hassan",
year = "2012",
month = "4",
day = "1",
doi = "10.1179/1120009X12Z.00000000017",
language = "English (US)",
volume = "24",
pages = "87--92",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "2",

}

TY - JOUR

T1 - In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia

AU - Dhabaan, Ghulam N.

AU - AbuBakar, Sazaly

AU - Shorman, Mahmoud

AU - Hassan, Hamimah

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The in vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75% of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5% showed intermediate resistance with MIC ranging between 0.032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40% and 60%, respectively, with a significantly lower MIC range of 0.5-4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.

AB - The in vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75% of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5% showed intermediate resistance with MIC ranging between 0.032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40% and 60%, respectively, with a significantly lower MIC range of 0.5-4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.

UR - http://www.scopus.com/inward/record.url?scp=84866236703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866236703&partnerID=8YFLogxK

U2 - 10.1179/1120009X12Z.00000000017

DO - 10.1179/1120009X12Z.00000000017

M3 - Article

VL - 24

SP - 87

EP - 92

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - 2

ER -