In vitro activity of various antimicrobial agents against Staphylococcus aureus isolates including fluoroquinolone- and oxacillin-resistant strains

Kenneth E. Aldridge, Ronald N. Jones, Arthur L. Barry, Michael S. Gelfand

Research output: Contribution to journalArticle

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Abstract

To determine susceptibility to 31 old and new antimicrobials, 44 strains of Staphylococcus aureus, most resistant to oxacillin and ciprofloxacin and isolated in a community hospital, were tested in vitro. For the peptide/peptide-derivative compounds, with the exception of mersacidin, all strains were inhibited by ≤2 μg/ml. Minimum inhibitory concentration (MIC)90 values indicated mupirocin, teicoplanin, and MDL 62211 to be fourfold more active than vancomycin, ramoplanin, and decaplanin. For fluoroquinolones, ciprofloxacin-resistant S. aureus exhibited high-level cross-resistance to ofloxacin, norfloxacin, fleroxacin, enoxacin, and Ro 23-9424. WIN 57253, a new fluorinated naphthyridine, showed good activity against these strains. Among the β-lactams, the penem-derivative compounds (imipenem, meropenem, FCE 22101, and HRE 664) had the greatest activity, although resistance to each compound was detected among oxacillin-resistant S. aureus. The presence of tazobactam reduced the piperacillin MIC90 fourfold. Oxacillin-susceptible strains were susceptible to cephalosporins/cephamycins, whereas most oxacillin-resistant strains exhibited resistance. This study has shown that certain old and new quinolones and peptide-derivative compounds have good in vitro activity against multiply resistant strains of S. aureus.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume15
Issue number6
DOIs
StatePublished - Aug 1992

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Oxacillin
meropenem
Fluoroquinolones
Anti-Infective Agents
Staphylococcus aureus
Ciprofloxacin
ramoplanin
Peptides
Fleroxacin
Cephamycins
Naphthyridines
Enoxacin
Mupirocin
Teicoplanin
Lactams
Norfloxacin
Ofloxacin
Imipenem
Quinolones
Community Hospital

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

In vitro activity of various antimicrobial agents against Staphylococcus aureus isolates including fluoroquinolone- and oxacillin-resistant strains. / Aldridge, Kenneth E.; Jones, Ronald N.; Barry, Arthur L.; Gelfand, Michael S.

In: Diagnostic Microbiology and Infectious Disease, Vol. 15, No. 6, 08.1992, p. 517-521.

Research output: Contribution to journalArticle

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