In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles

Baher Fahmy, Liren Ding, Dahui You, Slawo Lomnicki, Barry Dellinger, Stephania Cormier

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Strong correlations exist between exposure to PM2.5 and adverse pulmonary effects. PM2.5 consists of fine (≤2.5μm) and ultrafine (≤0.1μm) particles with ultrafine particles accounting for >70% of the total particles. Environmentally persistent free radicals (EPFRs) have recently been identified in airborne PM2.5. To determine the adverse pulmonary effects of EPFRs associated with exposure to elevated levels of PM2.5, we engineered 2.5μm surrogate EPFR-particle systems. We demonstrated that EPFRs generated greater oxidative stress in vitro, which was partly responsible for the enhanced cytotoxicity following exposure. In vivo studies using rats exposed to EPFRs containing particles demonstrated minimal adverse pulmonary effects. Additional studies revealed that fine particles failed to reach the alveolar region. Overall, our study implies qualitative differences between the health effects of PM size fractions.

Original languageEnglish (US)
Pages (from-to)173-182
Number of pages10
JournalEnvironmental Toxicology and Pharmacology
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2010

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Free Radicals
Lung
Oxidative stress
Cytotoxicity
Rats
Oxidative Stress
In Vitro Techniques
Health
Ultrafine

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles. / Fahmy, Baher; Ding, Liren; You, Dahui; Lomnicki, Slawo; Dellinger, Barry; Cormier, Stephania.

In: Environmental Toxicology and Pharmacology, Vol. 29, No. 2, 01.03.2010, p. 173-182.

Research output: Contribution to journalArticle

Fahmy, Baher ; Ding, Liren ; You, Dahui ; Lomnicki, Slawo ; Dellinger, Barry ; Cormier, Stephania. / In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles. In: Environmental Toxicology and Pharmacology. 2010 ; Vol. 29, No. 2. pp. 173-182.
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