In vitro antioxidant and in Vivo antidiarrhoeal activity of hydromethanolic extract of Xanthium indicum Koenig. Leaves

Raushanara Akter, S M Raquibul Hasan, Md Mokarram Hossain, Mariam Jamila, Md Ehsanul Hoque Mazumder, Shafiqur Rahman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Xanthium indicum Koenig. is a medicinal herb belonging to the family Compositae, which has been reported to possess strong diaphoretic, antimalarial, anticancer and demulcent properties according to indigenous systems of medicine in Indian Sub-Continent. But its antidiarrhoeal and antioxidant potential is still unknown. Therefore, the present study was designed to investigate antioxidant and antidiarrhoeal properties of hydromethanol extract of X. indicum leaves. The extract was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and nitric oxide (NO) scavenging assays. The extract displayed a dose dependent scavenging of DPPH radical and NO. The extract was also studied for antidiarrhoeal property using castor oil and MgSO4-induced diarrhoeal model and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extract delayed the intestinal transit of charcoal meal in test animals as compared to the control and the results were statistically significant (p <0.05). The results of the present study confirm antioxidant and antidiarrhoeal potential of the leaves of X. indicum, thus may provide the scientific basis for the traditional uses of this plant as the modality for diarrhoea and other pathological conditions where free radicals are implicated.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalEuropean Journal of Scientific Research
Volume33
Issue number2
StatePublished - Jan 1 2009

Fingerprint

Xanthium
antidiarrheal effect
Antidiarrheals
Xanthium strumarium
Antioxidants
antioxidant
Scavenging
Leaves
Nitric Oxide
antioxidants
Dose
Charcoal
Nitric oxide
extracts
nitric oxide
charcoal
leaves
Diarrhea
Animals
animal tests

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Mathematics(all)
  • Materials Science(all)
  • Agricultural and Biological Sciences(all)
  • Engineering(all)
  • Earth and Planetary Sciences(all)

Cite this

In vitro antioxidant and in Vivo antidiarrhoeal activity of hydromethanolic extract of Xanthium indicum Koenig. Leaves. / Akter, Raushanara; Hasan, S M Raquibul; Hossain, Md Mokarram; Jamila, Mariam; Mazumder, Md Ehsanul Hoque; Rahman, Shafiqur.

In: European Journal of Scientific Research, Vol. 33, No. 2, 01.01.2009, p. 305-312.

Research output: Contribution to journalArticle

Akter, Raushanara ; Hasan, S M Raquibul ; Hossain, Md Mokarram ; Jamila, Mariam ; Mazumder, Md Ehsanul Hoque ; Rahman, Shafiqur. / In vitro antioxidant and in Vivo antidiarrhoeal activity of hydromethanolic extract of Xanthium indicum Koenig. Leaves. In: European Journal of Scientific Research. 2009 ; Vol. 33, No. 2. pp. 305-312.
@article{9c67aa4395a34faca4fb6c51b766fd1f,
title = "In vitro antioxidant and in Vivo antidiarrhoeal activity of hydromethanolic extract of Xanthium indicum Koenig. Leaves",
abstract = "Xanthium indicum Koenig. is a medicinal herb belonging to the family Compositae, which has been reported to possess strong diaphoretic, antimalarial, anticancer and demulcent properties according to indigenous systems of medicine in Indian Sub-Continent. But its antidiarrhoeal and antioxidant potential is still unknown. Therefore, the present study was designed to investigate antioxidant and antidiarrhoeal properties of hydromethanol extract of X. indicum leaves. The extract was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and nitric oxide (NO) scavenging assays. The extract displayed a dose dependent scavenging of DPPH radical and NO. The extract was also studied for antidiarrhoeal property using castor oil and MgSO4-induced diarrhoeal model and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extract delayed the intestinal transit of charcoal meal in test animals as compared to the control and the results were statistically significant (p <0.05). The results of the present study confirm antioxidant and antidiarrhoeal potential of the leaves of X. indicum, thus may provide the scientific basis for the traditional uses of this plant as the modality for diarrhoea and other pathological conditions where free radicals are implicated.",
author = "Raushanara Akter and Hasan, {S M Raquibul} and Hossain, {Md Mokarram} and Mariam Jamila and Mazumder, {Md Ehsanul Hoque} and Shafiqur Rahman",
year = "2009",
month = "1",
day = "1",
language = "English (US)",
volume = "33",
pages = "305--312",
journal = "European Journal of Scientific Research",
issn = "1450-202X",
publisher = "European Journals Inc.",
number = "2",

}

TY - JOUR

T1 - In vitro antioxidant and in Vivo antidiarrhoeal activity of hydromethanolic extract of Xanthium indicum Koenig. Leaves

AU - Akter, Raushanara

AU - Hasan, S M Raquibul

AU - Hossain, Md Mokarram

AU - Jamila, Mariam

AU - Mazumder, Md Ehsanul Hoque

AU - Rahman, Shafiqur

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Xanthium indicum Koenig. is a medicinal herb belonging to the family Compositae, which has been reported to possess strong diaphoretic, antimalarial, anticancer and demulcent properties according to indigenous systems of medicine in Indian Sub-Continent. But its antidiarrhoeal and antioxidant potential is still unknown. Therefore, the present study was designed to investigate antioxidant and antidiarrhoeal properties of hydromethanol extract of X. indicum leaves. The extract was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and nitric oxide (NO) scavenging assays. The extract displayed a dose dependent scavenging of DPPH radical and NO. The extract was also studied for antidiarrhoeal property using castor oil and MgSO4-induced diarrhoeal model and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extract delayed the intestinal transit of charcoal meal in test animals as compared to the control and the results were statistically significant (p <0.05). The results of the present study confirm antioxidant and antidiarrhoeal potential of the leaves of X. indicum, thus may provide the scientific basis for the traditional uses of this plant as the modality for diarrhoea and other pathological conditions where free radicals are implicated.

AB - Xanthium indicum Koenig. is a medicinal herb belonging to the family Compositae, which has been reported to possess strong diaphoretic, antimalarial, anticancer and demulcent properties according to indigenous systems of medicine in Indian Sub-Continent. But its antidiarrhoeal and antioxidant potential is still unknown. Therefore, the present study was designed to investigate antioxidant and antidiarrhoeal properties of hydromethanol extract of X. indicum leaves. The extract was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and nitric oxide (NO) scavenging assays. The extract displayed a dose dependent scavenging of DPPH radical and NO. The extract was also studied for antidiarrhoeal property using castor oil and MgSO4-induced diarrhoeal model and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extract delayed the intestinal transit of charcoal meal in test animals as compared to the control and the results were statistically significant (p <0.05). The results of the present study confirm antioxidant and antidiarrhoeal potential of the leaves of X. indicum, thus may provide the scientific basis for the traditional uses of this plant as the modality for diarrhoea and other pathological conditions where free radicals are implicated.

UR - http://www.scopus.com/inward/record.url?scp=68349135013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68349135013&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:68349135013

VL - 33

SP - 305

EP - 312

JO - European Journal of Scientific Research

JF - European Journal of Scientific Research

SN - 1450-202X

IS - 2

ER -