In vitro effects of boron-containing compounds upon glioblastoma cells

Sarah F. Bailey, George Kabalka, Joseph E. Fuhr

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Boron-neutron capture therapy (BNCT) is currently under investigation as a novel therapeutic modality for glioblastoma. This study was undertaken to determine whether boron-containing compounds 4-borono-2-fluoro-D,L- phenylalanine (FBPA) and FBPA-fructose have direct effects upon kinetics of A172, a glioblastoma cell line. Flow cytometry analyzed cell-cycle distribution and S-phase kinetics (bromo deoxyuridine [BUdR] incorporation). BUdR incorporation was increased during a 1-hr pulse after 24-hr or 72-hr exposure of cells to varying concentrations of FBPA or FBPA-fructose. Results suggest that boron-containing compounds may effect cell kinetics apart from neutron activation, and this effect should be further evaluated for potential impact upon tumor responsiveness to BNCT.

Original languageEnglish (US)
Pages (from-to)452-455
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume216
Issue number3
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

Boron Compounds
Boron
Glioblastoma
Boron Neutron Capture Therapy
Bromodeoxyuridine
Fructose
Neutrons
Kinetics
Deoxyuridine
Cells
S Phase
Flow cytometry
Cell Cycle
Flow Cytometry
Phenylalanine
Tumors
Cell Line
Chemical activation
In Vitro Techniques
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

In vitro effects of boron-containing compounds upon glioblastoma cells. / Bailey, Sarah F.; Kabalka, George; Fuhr, Joseph E.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 216, No. 3, 01.12.1997, p. 452-455.

Research output: Contribution to journalArticle

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