In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

Mohammed Aktar Sayeed, S. M Raquibul Hasan, Md Sohel Rana

Research output: Contribution to journalArticle

Abstract

The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement. Job's analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon's plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo.

Original languageEnglish (US)
Pages (from-to)189
Number of pages1
JournalLatin American Journal of Pharmacy
Volume30
Issue number1
StatePublished - 2011
Externally publishedYes

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Ketotifen
Metformin
Drug Interactions
Animal Models
Pharmaceutical Preparations
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

In vitro study on interaction of ketotifen fumarate with metformin hydrochloride. / Sayeed, Mohammed Aktar; Hasan, S. M Raquibul; Rana, Md Sohel.

In: Latin American Journal of Pharmacy, Vol. 30, No. 1, 2011, p. 189.

Research output: Contribution to journalArticle

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