In vivo boron-11 MRI and MRS using (B24H22S2)4- in the rat

George Kabalka, Guang Qiang Cheng, Peter Bendel, Peggy L. Micca, Daniel N. Slatkin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In vivo boron-11 magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were performed on a rat that had been infused with a potential boron neutron capture therapy agent, Na4B24H22S2, using methods for detecting nuclei with a short T2 relaxation time. MRI and MRS were also performed on a euthanized rat that had been similarly infused in vivo. Boron-11 spectral intensities decreased in the living rat over a 25-h period. The results demonstrate the capability of MRI and MRS to noninvasively monitor the distribution and excretion of boron agents in vivo.

Original languageEnglish (US)
Pages (from-to)969-973
Number of pages5
JournalMagnetic Resonance Imaging
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1991

Fingerprint

Magnetic resonance spectroscopy
Boron
Magnetic resonance
Rats
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Imaging techniques
Boron Neutron Capture Therapy
Relaxation time
Neutrons

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

In vivo boron-11 MRI and MRS using (B24H22S2)4- in the rat. / Kabalka, George; Cheng, Guang Qiang; Bendel, Peter; Micca, Peggy L.; Slatkin, Daniel N.

In: Magnetic Resonance Imaging, Vol. 9, No. 6, 01.01.1991, p. 969-973.

Research output: Contribution to journalArticle

Kabalka, George ; Cheng, Guang Qiang ; Bendel, Peter ; Micca, Peggy L. ; Slatkin, Daniel N. / In vivo boron-11 MRI and MRS using (B24H22S2)4- in the rat. In: Magnetic Resonance Imaging. 1991 ; Vol. 9, No. 6. pp. 969-973.
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