In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated candidiasis

Soňa Kucharíková, Helene Tournu, Michelle Holtappels, Patrick Van Dijck, Katrien Lagrou

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.

Original languageEnglish (US)
Pages (from-to)4474-4475
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number10
DOIs
StatePublished - Oct 1 2010

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anidulafungin
Candidiasis
Biofilms
Candida albicans
Catheters
Fluconazole
Intraperitoneal Injections
Cell Count

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated candidiasis. / Kucharíková, Soňa; Tournu, Helene; Holtappels, Michelle; Van Dijck, Patrick; Lagrou, Katrien.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 10, 01.10.2010, p. 4474-4475.

Research output: Contribution to journalArticle

Kucharíková, Soňa ; Tournu, Helene ; Holtappels, Michelle ; Van Dijck, Patrick ; Lagrou, Katrien. / In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated candidiasis. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 10. pp. 4474-4475.
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