In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress

Michael J. Blake, Thaddeus Nowak, Nikki J. Holbrook

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Regional localization of HSP70 expression in brain of rats exposed to increased ambient temperatures was examined using in situ hybridization. In addition to the cerebellar granule cell layer and choroid plexus, selective hybridization was observed in the hippocampal dentate gyrus, paraventricular and dorsomedial hypothalamic nuclei, median eminence, and medial habenula. Apparently, cells in brain regions coordinating the neuroendocrine response to stress show a preferential induction of cellular stress proteins in response to heat.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalMolecular Brain Research
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Fever
Dorsomedial Hypothalamic Nucleus
Habenula
Parahippocampal Gyrus
Messenger RNA
Median Eminence
Choroid Plexus
Paraventricular Hypothalamic Nucleus
Dentate Gyrus
Brain
Heat-Shock Proteins
In Situ Hybridization
Hot Temperature
Temperature

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress. / Blake, Michael J.; Nowak, Thaddeus; Holbrook, Nikki J.

In: Molecular Brain Research, Vol. 8, No. 1, 01.01.1990, p. 89-92.

Research output: Contribution to journalArticle

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