In vivo metabolic activity of the suprachiasmatic nuclei

non-uniform intranuclear distribution of 14C-labeled deoxyglucose uptake

William J. Schwartz, Ralph Lydic, Martin C. Moore-Ede

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Anatomical techniques have shown that the suprachiasmatic nuclei (SCN) are organized into distinct dorsomedial and ventrolateral subdivisions. As a functional correlate to this morphological organization, the intranuclear distribution of SCN glucose utilization was mapped using the autoradiographic 14C-labeled deoxyglucose method. In nocturnal rats and diurnal squirrel monkeys injected with the tracer during the light portion of the light-dark cycle, the middle of the SCN was metabolicaly more active than its rostral or caudal ends. No obvious dorsomedial/ventrolateral parcellation of SCN functional activity was disclosed. The rostrocaudal metabolic contour persisted unchanged activity was generally found at the largest cross-sectional area). This result is discussed with respect to its implications for the generation of circadian rhythmicity by the endogenous pacemaker in the SCN.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalBrain Research
Volume424
Issue number2
DOIs
StatePublished - Oct 27 1987
Externally publishedYes

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Suprachiasmatic Nucleus
Deoxyglucose
Saimiri
Photoperiod
Periodicity
Light
Glucose

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

In vivo metabolic activity of the suprachiasmatic nuclei : non-uniform intranuclear distribution of 14C-labeled deoxyglucose uptake. / Schwartz, William J.; Lydic, Ralph; Moore-Ede, Martin C.

In: Brain Research, Vol. 424, No. 2, 27.10.1987, p. 249-257.

Research output: Contribution to journalArticle

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