In vivo optical characterization of pediatric epileptogenic lesions

W. C. Lin, J. Ragheb, S. Bhatia, Mahlon Johnson, D. Sandberg, A. Fernandez, G. Morrison, M. Duchowny, P. Jayakar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Epileptogenic lesions and their margins are often difficult to define intraoperatively. We hypothesize that optical spectroscopy can detect unique pathophysiological features of epileptogenic lesions in children and hence differentiate them from normal brain. This hypothesis was tested by comparing the in vivo optical and fluorescence characteristics of epileptogenic brain lesions (non-neoplastic) with those of normal brain. Patients were recruited from those receiving epilepsy surgeries at Miami Children's Hospital. Using a portable spectroscopic system, optical characterization of brain was performed intraoperatively. Fluorescence spectra were measured at 337 nm excitation, and diffuse reflectance spectra were measured between 400 and 850 nm. To date, seven epilepsy patients have been enrolled in the study. A couple interesting trends have been observed in the recorded optical spectra. First, sites within the resection zone, as defined by the intracranial electroencephalogram data, often show higher diffuse reflectance signals than normal sites do. This is especially prominent around 500 nm and between 650 and 850 nm. Secondly, several investigated sites with abnormal electroencephalogram and/or pathology show a unique blue shift in their fluorescence spectra, which is not seen in other cases.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics III
DOIs
StatePublished - Aug 31 2007
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics III - San Jose, CA, United States
Duration: Jan 20 2007Jan 21 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6424
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics III
CountryUnited States
CitySan Jose, CA
Period1/20/071/21/07

Fingerprint

Pediatrics
lesions
brain
Brain
epilepsy
electroencephalography
Fluorescence
Electroencephalography
fluorescence
Epilepsy
reflectance
Optical Devices
pathology
Pathology
blue shift
surgery
Optical systems
Surgery
optical spectrum
margins

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Lin, W. C., Ragheb, J., Bhatia, S., Johnson, M., Sandberg, D., Fernandez, A., ... Jayakar, P. (2007). In vivo optical characterization of pediatric epileptogenic lesions. In Photonic Therapeutics and Diagnostics III [642427] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6424). https://doi.org/10.1117/12.700717

In vivo optical characterization of pediatric epileptogenic lesions. / Lin, W. C.; Ragheb, J.; Bhatia, S.; Johnson, Mahlon; Sandberg, D.; Fernandez, A.; Morrison, G.; Duchowny, M.; Jayakar, P.

Photonic Therapeutics and Diagnostics III. 2007. 642427 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6424).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lin, WC, Ragheb, J, Bhatia, S, Johnson, M, Sandberg, D, Fernandez, A, Morrison, G, Duchowny, M & Jayakar, P 2007, In vivo optical characterization of pediatric epileptogenic lesions. in Photonic Therapeutics and Diagnostics III., 642427, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6424, Photonic Therapeutics and Diagnostics III, San Jose, CA, United States, 1/20/07. https://doi.org/10.1117/12.700717
Lin WC, Ragheb J, Bhatia S, Johnson M, Sandberg D, Fernandez A et al. In vivo optical characterization of pediatric epileptogenic lesions. In Photonic Therapeutics and Diagnostics III. 2007. 642427. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.700717
Lin, W. C. ; Ragheb, J. ; Bhatia, S. ; Johnson, Mahlon ; Sandberg, D. ; Fernandez, A. ; Morrison, G. ; Duchowny, M. ; Jayakar, P. / In vivo optical characterization of pediatric epileptogenic lesions. Photonic Therapeutics and Diagnostics III. 2007. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
@inproceedings{bebd4e5f46ea46caacdb71dee7ca42aa,
title = "In vivo optical characterization of pediatric epileptogenic lesions",
abstract = "Epileptogenic lesions and their margins are often difficult to define intraoperatively. We hypothesize that optical spectroscopy can detect unique pathophysiological features of epileptogenic lesions in children and hence differentiate them from normal brain. This hypothesis was tested by comparing the in vivo optical and fluorescence characteristics of epileptogenic brain lesions (non-neoplastic) with those of normal brain. Patients were recruited from those receiving epilepsy surgeries at Miami Children's Hospital. Using a portable spectroscopic system, optical characterization of brain was performed intraoperatively. Fluorescence spectra were measured at 337 nm excitation, and diffuse reflectance spectra were measured between 400 and 850 nm. To date, seven epilepsy patients have been enrolled in the study. A couple interesting trends have been observed in the recorded optical spectra. First, sites within the resection zone, as defined by the intracranial electroencephalogram data, often show higher diffuse reflectance signals than normal sites do. This is especially prominent around 500 nm and between 650 and 850 nm. Secondly, several investigated sites with abnormal electroencephalogram and/or pathology show a unique blue shift in their fluorescence spectra, which is not seen in other cases.",
author = "Lin, {W. C.} and J. Ragheb and S. Bhatia and Mahlon Johnson and D. Sandberg and A. Fernandez and G. Morrison and M. Duchowny and P. Jayakar",
year = "2007",
month = "8",
day = "31",
doi = "10.1117/12.700717",
language = "English (US)",
isbn = "0819465372",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photonic Therapeutics and Diagnostics III",

}

TY - GEN

T1 - In vivo optical characterization of pediatric epileptogenic lesions

AU - Lin, W. C.

AU - Ragheb, J.

AU - Bhatia, S.

AU - Johnson, Mahlon

AU - Sandberg, D.

AU - Fernandez, A.

AU - Morrison, G.

AU - Duchowny, M.

AU - Jayakar, P.

PY - 2007/8/31

Y1 - 2007/8/31

N2 - Epileptogenic lesions and their margins are often difficult to define intraoperatively. We hypothesize that optical spectroscopy can detect unique pathophysiological features of epileptogenic lesions in children and hence differentiate them from normal brain. This hypothesis was tested by comparing the in vivo optical and fluorescence characteristics of epileptogenic brain lesions (non-neoplastic) with those of normal brain. Patients were recruited from those receiving epilepsy surgeries at Miami Children's Hospital. Using a portable spectroscopic system, optical characterization of brain was performed intraoperatively. Fluorescence spectra were measured at 337 nm excitation, and diffuse reflectance spectra were measured between 400 and 850 nm. To date, seven epilepsy patients have been enrolled in the study. A couple interesting trends have been observed in the recorded optical spectra. First, sites within the resection zone, as defined by the intracranial electroencephalogram data, often show higher diffuse reflectance signals than normal sites do. This is especially prominent around 500 nm and between 650 and 850 nm. Secondly, several investigated sites with abnormal electroencephalogram and/or pathology show a unique blue shift in their fluorescence spectra, which is not seen in other cases.

AB - Epileptogenic lesions and their margins are often difficult to define intraoperatively. We hypothesize that optical spectroscopy can detect unique pathophysiological features of epileptogenic lesions in children and hence differentiate them from normal brain. This hypothesis was tested by comparing the in vivo optical and fluorescence characteristics of epileptogenic brain lesions (non-neoplastic) with those of normal brain. Patients were recruited from those receiving epilepsy surgeries at Miami Children's Hospital. Using a portable spectroscopic system, optical characterization of brain was performed intraoperatively. Fluorescence spectra were measured at 337 nm excitation, and diffuse reflectance spectra were measured between 400 and 850 nm. To date, seven epilepsy patients have been enrolled in the study. A couple interesting trends have been observed in the recorded optical spectra. First, sites within the resection zone, as defined by the intracranial electroencephalogram data, often show higher diffuse reflectance signals than normal sites do. This is especially prominent around 500 nm and between 650 and 850 nm. Secondly, several investigated sites with abnormal electroencephalogram and/or pathology show a unique blue shift in their fluorescence spectra, which is not seen in other cases.

UR - http://www.scopus.com/inward/record.url?scp=34548258805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548258805&partnerID=8YFLogxK

U2 - 10.1117/12.700717

DO - 10.1117/12.700717

M3 - Conference contribution

SN - 0819465372

SN - 9780819465375

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics III

ER -