In-vivo optical detection of brain tumor and tumor margin

A combined autofluorescence and diffuse reflectance spectroscopic study

Shovan K. Majumder, Steven Gebhart, Reid Thompson, Kyle D. Weaver, Mahlon Johnson, Wei Chiang Lin, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recently, optical spectroscopy has shown considerable promise to be used as a potential clinical tool for human brain tumor detection and therapeutic guidance. Our group showed for the first time the possibility of using combined autofluorescence and diffuse reflectance spectroscopy and established its applicability for human brain tumor demarcation in previous in vitro and in vivo studies. We report in this paper the results of a clinical study designed to further evaluate the efficacy of the approach for demarcation of brain tumors and tumor margins from normal brain tissues in intra-operative clinical setting. Using a portable system, optical spectra were collected from the brain of 110 patients undergoing craniotomy at the Vanderbilt University Medical Center. Spectral measurements were taken from multiple sites of tumor core, tumor margin and normal areas of brain tissues and the resulting spectra were correlated with the corresponding histopathologic diagnosis. Using histology as the gold standard, a probabilistic multi-class diagnostic algorithm was developed to simultaneously distinguish tumor core and tumor margin from normal brain tissue sites using independent training and validation sets of data. An unbiased estimate of the accuracy of the model indicates that combined autofluorescence and diffuse reflectance spectroscopy was able to distinguish tumor core and tumor margin from normal brain tissues with an average predictive accuracy of ∼88%.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems V
Volume6430
DOIs
StatePublished - Apr 30 2007
Externally publishedYes
EventAdvanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States
Duration: Jan 21 2007Jan 27 2007

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems V
CountryUnited States
CitySan Jose, CA
Period1/21/071/27/07

Fingerprint

Brain Neoplasms
brain
Tumors
margins
Brain
tumors
reflectance
Neoplasms
Spectrum Analysis
Tissue
Optical Devices
Craniotomy
Spectroscopy
spectroscopy
Histology
histology
Optical systems
optical spectrum
education
estimates

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Majumder, S. K., Gebhart, S., Thompson, R., Weaver, K. D., Johnson, M., Lin, W. C., & Mahadevan-Jansen, A. (2007). In-vivo optical detection of brain tumor and tumor margin: A combined autofluorescence and diffuse reflectance spectroscopic study. In Advanced Biomedical and Clinical Diagnostic Systems V (Vol. 6430). [64300F] https://doi.org/10.1117/12.724875

In-vivo optical detection of brain tumor and tumor margin : A combined autofluorescence and diffuse reflectance spectroscopic study. / Majumder, Shovan K.; Gebhart, Steven; Thompson, Reid; Weaver, Kyle D.; Johnson, Mahlon; Lin, Wei Chiang; Mahadevan-Jansen, Anita.

Advanced Biomedical and Clinical Diagnostic Systems V. Vol. 6430 2007. 64300F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Majumder, SK, Gebhart, S, Thompson, R, Weaver, KD, Johnson, M, Lin, WC & Mahadevan-Jansen, A 2007, In-vivo optical detection of brain tumor and tumor margin: A combined autofluorescence and diffuse reflectance spectroscopic study. in Advanced Biomedical and Clinical Diagnostic Systems V. vol. 6430, 64300F, Advanced Biomedical and Clinical Diagnostic Systems V, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.724875
Majumder SK, Gebhart S, Thompson R, Weaver KD, Johnson M, Lin WC et al. In-vivo optical detection of brain tumor and tumor margin: A combined autofluorescence and diffuse reflectance spectroscopic study. In Advanced Biomedical and Clinical Diagnostic Systems V. Vol. 6430. 2007. 64300F https://doi.org/10.1117/12.724875
Majumder, Shovan K. ; Gebhart, Steven ; Thompson, Reid ; Weaver, Kyle D. ; Johnson, Mahlon ; Lin, Wei Chiang ; Mahadevan-Jansen, Anita. / In-vivo optical detection of brain tumor and tumor margin : A combined autofluorescence and diffuse reflectance spectroscopic study. Advanced Biomedical and Clinical Diagnostic Systems V. Vol. 6430 2007.
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