In vivo response to cross-linked polyethylene and polycarbonate-urethane particles

Richard Smith, Anobel Maghsoodpour, Nadim James Hallab

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This study was undertaken to examine macrophage response to polycarbonate-urethane, a proposed alternative material to polyethylene in acetabular components of total hip arthroplasty. Polyethylene wear debris from total joint replacements has been linked to osteolysis and implant lifespan. It has been shown in vitro, that polyethylene particles cleaned of endotoxin generate less of an inflammatory cytokine response than endotoxin bound particles. Comparative particle induced effects on implant fixation were tested using endotoxin free cross-linked ultra-high molecular weight polyethylene (x-UHMWPE) and polycarbonate-urethane (PCU) particles with and without intraperitoneal injection (IP) of lipopolysaccharide (LPS) using a Ti-alloy femoral intramedullary nail rat model. MicroCT and mechanical testing assessment of peri-implant bone indicated significantly less bone and lower fixation strength, respectively, when the implant was surrounded by xUHMWPE particles compared to PCU particles (with and without LPS IP). This indicates particles of PCU may be less disruptive to bone-implant fixation than x-UHMWPE in vivo, under both LPS free and challenged conditions.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume93
Issue number1
DOIs
StatePublished - Apr 1 2010

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polycarbonate
Urethane
Polyethylene
Polycarbonates
Ultrahigh molecular weight polyethylenes
Polyethylenes
Endotoxins
Lipopolysaccharides
Bone
Arthroplasty
Nails
Mechanical testing
Macrophages
Debris
Rats
Wear of materials
Cytokines

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

In vivo response to cross-linked polyethylene and polycarbonate-urethane particles. / Smith, Richard; Maghsoodpour, Anobel; Hallab, Nadim James.

In: Journal of Biomedical Materials Research - Part A, Vol. 93, No. 1, 01.04.2010, p. 227-234.

Research output: Contribution to journalArticle

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