Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125i‐radioimmunoassay

John Stuart, Eugene H. Huffstutter, Alexander S. Townes, Andrew Kang

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I‐radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.

Original languageEnglish (US)
Pages (from-to)832-840
Number of pages9
JournalArthritis & Rheumatism
Volume26
Issue number7
DOIs
StatePublished - Jan 1 1983

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Antibody Specificity
Rheumatic Diseases
Rheumatoid Arthritis
Collagen
Antibodies
Incidence
Gout
Synovial Fluid
Serum
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125i‐radioimmunoassay. / Stuart, John; Huffstutter, Eugene H.; Townes, Alexander S.; Kang, Andrew.

In: Arthritis & Rheumatism, Vol. 26, No. 7, 01.01.1983, p. 832-840.

Research output: Contribution to journalArticle

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