Incidence of endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using topical lidocaine gel anesthesia

Zachary Daniel Inman, Nicholas Anderson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to determine the incidence of infectious endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using 2% topical lidocaine gel anesthesia. Methods: Retrospective chart review of 4690 consecutive intravitreal injections of antivascular endothelial growth factor medications using 2% topical lidocaine gel anesthesia. All patients had at least 6 weeks of follow-up. Results: A total of 608 patients underwent intravitreal injection of antivascular endothelial growth factor medications during the study period. There were 428 injections of pegaptanib sodium, 1841 injections of bevacizumab, and 2421 injections of ranibizumab. There were no cases of infectious endophthalmitis. The per-injection infection rate was 0.0% (95% confidence interval, 0.0-0.06%). Conclusion: The incidence of infectious endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using 2% topical lidocaine gel anesthesia is low.

Original languageEnglish (US)
Pages (from-to)669-672
Number of pages4
JournalRetina
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

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Endothelial Growth Factors
Intravitreal Injections
Endophthalmitis
Lidocaine
Anesthesia
Gels
Injections
Incidence
Confidence Intervals
Infection

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Incidence of endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using topical lidocaine gel anesthesia. / Inman, Zachary Daniel; Anderson, Nicholas.

In: Retina, Vol. 31, No. 4, 01.04.2011, p. 669-672.

Research output: Contribution to journalArticle

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abstract = "Purpose: The purpose of this study was to determine the incidence of infectious endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using 2{\%} topical lidocaine gel anesthesia. Methods: Retrospective chart review of 4690 consecutive intravitreal injections of antivascular endothelial growth factor medications using 2{\%} topical lidocaine gel anesthesia. All patients had at least 6 weeks of follow-up. Results: A total of 608 patients underwent intravitreal injection of antivascular endothelial growth factor medications during the study period. There were 428 injections of pegaptanib sodium, 1841 injections of bevacizumab, and 2421 injections of ranibizumab. There were no cases of infectious endophthalmitis. The per-injection infection rate was 0.0{\%} (95{\%} confidence interval, 0.0-0.06{\%}). Conclusion: The incidence of infectious endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using 2{\%} topical lidocaine gel anesthesia is low.",
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