Increased Airway Leukotriene Levels in Infants With Severe Bronchopulmonary Dysplasia

Robert Mirro, William Armstead, Charles Leffler

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The sulphidopeptide leukotrienes (C4, D4, and E4) are potent airway constrictors that have been detected in the airways of infants with pulmonary hypertension and viral infections. The present study was undertaken to test the hypothesis that leukotrienes in tracheal lavage fluid are elevated in bronchopulmonary dysplasia. Twenty-six intubated infants (10 with bronchopulmonary dysplasia, 9 with hyaline membrane disease, and 7 normal controls) had tracheal lavage leukotriene levels determined by radioimmunoassay. Lavage fluid cell counts (alveolar macrophages) and leukotriene levels were significantly increased in infants with severe bronchopulmonary dysplasia. The increased concentration of leukotrienes seen in the infants with bronchopulmonary dysplasia would suggest a possible role for these compounds in the pathophysiology of this disease.

Original languageEnglish (US)
Pages (from-to)160-161
Number of pages2
JournalAmerican Journal of Diseases of Children
Volume144
Issue number2
DOIs
StatePublished - Jan 1 1990

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Bronchopulmonary Dysplasia
Leukotrienes
Therapeutic Irrigation
Leukotriene E4
Hyaline Membrane Disease
Leukotriene D4
Leukotriene C4
Alveolar Macrophages
Virus Diseases
Pulmonary Hypertension
Radioimmunoassay
Cell Count

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased Airway Leukotriene Levels in Infants With Severe Bronchopulmonary Dysplasia. / Mirro, Robert; Armstead, William; Leffler, Charles.

In: American Journal of Diseases of Children, Vol. 144, No. 2, 01.01.1990, p. 160-161.

Research output: Contribution to journalArticle

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