Increased risk of myocardial infarction in depressed patients with type 2 diabetes

Jeffrey F. Scherrer, Lauren D. Garfield, Timothy Chrusciel, Paul Hauptman, Robert M. Carney, Kenneth E. Freedland, Richard Owen, William R. True, Patrick J. Lustman

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

OBJECTIVE - To investigate major depressive disorder (MDD), which complicates the course of type 2 diabetes and is associated with an increased risk of cardiovascular disease and death. This risk may be due to a greater susceptibility for myocardial infarction (MI) in depressed patients with type 2 diabetes compared with nondepressed patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - Veterans Administration electronic medical records were analyzed to identify a cohort free of cardiovascular disease in fiscal years 1999 and 2000, aged 25 to 80 years. ICD-9-CM codes were used to create a four-level risk group indicating 1) neither diabetes nor MDD (n = 214,749), 2) MDD alone (n = 77,568), 3) type 2 diabetes alone (n = 40,953), and 4) comorbid MDD and type 2 diabetes (n = 12,679). Age-adjusted Cox proportional hazards models were computed before and after adjusting for baseline sociodemographic and time-dependent covariates. RESULTS - After adjusting for covariates, patients with type 2 diabetes alone and patients with MDD alone were at ∼30% increased risk for MI, and patients with type 2 diabetes and MDD were at 82% increased risk for MI (hazard ratio 1.82 [95% CI 1.69-1.97]) compared with patients without either condition. CONCLUSIONS - Compared with patients with only diabetes or only MDD, individuals with type 2 diabetes and MDD are at increased risk for new-onset MI. Monitoring cardiovascular health in depressed patients with type 2 diabetes may reduce the risk of MI in this especially high-risk group.

Original languageEnglish (US)
Pages (from-to)1729-1734
Number of pages6
JournalDiabetes care
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2011

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Type 2 Diabetes Mellitus
Myocardial Infarction
Major Depressive Disorder
Cardiovascular Diseases
United States Department of Veterans Affairs
Electronic Health Records
International Classification of Diseases
Proportional Hazards Models
Research Design
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Scherrer, J. F., Garfield, L. D., Chrusciel, T., Hauptman, P., Carney, R. M., Freedland, K. E., ... Lustman, P. J. (2011). Increased risk of myocardial infarction in depressed patients with type 2 diabetes. Diabetes care, 34(8), 1729-1734. https://doi.org/10.2337/dc11-0031

Increased risk of myocardial infarction in depressed patients with type 2 diabetes. / Scherrer, Jeffrey F.; Garfield, Lauren D.; Chrusciel, Timothy; Hauptman, Paul; Carney, Robert M.; Freedland, Kenneth E.; Owen, Richard; True, William R.; Lustman, Patrick J.

In: Diabetes care, Vol. 34, No. 8, 01.08.2011, p. 1729-1734.

Research output: Contribution to journalArticle

Scherrer, JF, Garfield, LD, Chrusciel, T, Hauptman, P, Carney, RM, Freedland, KE, Owen, R, True, WR & Lustman, PJ 2011, 'Increased risk of myocardial infarction in depressed patients with type 2 diabetes', Diabetes care, vol. 34, no. 8, pp. 1729-1734. https://doi.org/10.2337/dc11-0031
Scherrer JF, Garfield LD, Chrusciel T, Hauptman P, Carney RM, Freedland KE et al. Increased risk of myocardial infarction in depressed patients with type 2 diabetes. Diabetes care. 2011 Aug 1;34(8):1729-1734. https://doi.org/10.2337/dc11-0031
Scherrer, Jeffrey F. ; Garfield, Lauren D. ; Chrusciel, Timothy ; Hauptman, Paul ; Carney, Robert M. ; Freedland, Kenneth E. ; Owen, Richard ; True, William R. ; Lustman, Patrick J. / Increased risk of myocardial infarction in depressed patients with type 2 diabetes. In: Diabetes care. 2011 ; Vol. 34, No. 8. pp. 1729-1734.
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