Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin

Relationship with body weight at diagnosis

Jennifer Evertsen, Ramin Alemzadeh, Xujing Wang

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Introduction: Several studies have confirmed the increasing rate of type 1 diabetes mellitus (T1DM) in children and the link with increasing BMI at diagnosis termed the 'accelerator hypothesis'. Our objective was to assess whether changing incidence of type 1 diabetes in a group of children and adolescent from the Midwest United States was associated with changes in BMI. Methods: Data from 1618 (52.1% M/47.9% F) newly-diagnosed children and adolescents (,19 years) with T1DM, admitted to Children's Hospital of Wisconsin (CHW) between January 1995 and December 2004, was analyzed in relationship to body mass index (BMI) standard deviation score (SDS). Results: An overall, 10-year cumulative incidence of 27.92 per 100,000 (19.12 to 41.72/100,000) was observed, with an average yearly cumulative incidence of 2.39%. The increase was largest in the younger age groups, 0-4, 5-9, and 10-14 having an average yearly increase of 2.4, 2.3, and 3.0%, respectively, corresponding to a relative 10-year increase of 25.3, 33.8, and 38.0%, respectively. Age at diagnosis was inversely correlated with BMI SDS (p,0.001) and remained significant for both males and females. Conclusions: Annual incidence of T1DM increased two-fold at CHW over the 10-year study period. The majority of the increase was observed in the youngest age groups, which also appeared to be the heaviest. This research adds to the growing literature supporting the hypothesis that excess weight gain during childhood may be a risk factor for early manifestation of T1DM.

Original languageEnglish (US)
Article numbere6873
JournalPloS one
Volume4
Issue number9
DOIs
StatePublished - Sep 3 2009

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Pediatrics
insulin-dependent diabetes mellitus
Medical problems
Type 1 Diabetes Mellitus
Body Weight
body mass index
Body Mass Index
incidence
body weight
Incidence
Age Groups
Midwestern United States
childhood
Weight Gain
Particle accelerators
risk factors
weight gain
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin : Relationship with body weight at diagnosis. / Evertsen, Jennifer; Alemzadeh, Ramin; Wang, Xujing.

In: PloS one, Vol. 4, No. 9, e6873, 03.09.2009.

Research output: Contribution to journalArticle

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abstract = "Introduction: Several studies have confirmed the increasing rate of type 1 diabetes mellitus (T1DM) in children and the link with increasing BMI at diagnosis termed the 'accelerator hypothesis'. Our objective was to assess whether changing incidence of type 1 diabetes in a group of children and adolescent from the Midwest United States was associated with changes in BMI. Methods: Data from 1618 (52.1{\%} M/47.9{\%} F) newly-diagnosed children and adolescents (,19 years) with T1DM, admitted to Children's Hospital of Wisconsin (CHW) between January 1995 and December 2004, was analyzed in relationship to body mass index (BMI) standard deviation score (SDS). Results: An overall, 10-year cumulative incidence of 27.92 per 100,000 (19.12 to 41.72/100,000) was observed, with an average yearly cumulative incidence of 2.39{\%}. The increase was largest in the younger age groups, 0-4, 5-9, and 10-14 having an average yearly increase of 2.4, 2.3, and 3.0{\%}, respectively, corresponding to a relative 10-year increase of 25.3, 33.8, and 38.0{\%}, respectively. Age at diagnosis was inversely correlated with BMI SDS (p,0.001) and remained significant for both males and females. Conclusions: Annual incidence of T1DM increased two-fold at CHW over the 10-year study period. The majority of the increase was observed in the youngest age groups, which also appeared to be the heaviest. This research adds to the growing literature supporting the hypothesis that excess weight gain during childhood may be a risk factor for early manifestation of T1DM.",
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N2 - Introduction: Several studies have confirmed the increasing rate of type 1 diabetes mellitus (T1DM) in children and the link with increasing BMI at diagnosis termed the 'accelerator hypothesis'. Our objective was to assess whether changing incidence of type 1 diabetes in a group of children and adolescent from the Midwest United States was associated with changes in BMI. Methods: Data from 1618 (52.1% M/47.9% F) newly-diagnosed children and adolescents (,19 years) with T1DM, admitted to Children's Hospital of Wisconsin (CHW) between January 1995 and December 2004, was analyzed in relationship to body mass index (BMI) standard deviation score (SDS). Results: An overall, 10-year cumulative incidence of 27.92 per 100,000 (19.12 to 41.72/100,000) was observed, with an average yearly cumulative incidence of 2.39%. The increase was largest in the younger age groups, 0-4, 5-9, and 10-14 having an average yearly increase of 2.4, 2.3, and 3.0%, respectively, corresponding to a relative 10-year increase of 25.3, 33.8, and 38.0%, respectively. Age at diagnosis was inversely correlated with BMI SDS (p,0.001) and remained significant for both males and females. Conclusions: Annual incidence of T1DM increased two-fold at CHW over the 10-year study period. The majority of the increase was observed in the youngest age groups, which also appeared to be the heaviest. This research adds to the growing literature supporting the hypothesis that excess weight gain during childhood may be a risk factor for early manifestation of T1DM.

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