Increasing ventilation pressure increases cortical subarachnoid cerebrospinall fluid prostanoids in newborn pigs

R. Mirro, W. Armstead, D. Busija, R. Green, Charles Leffler

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study examines the responses of pial arterioles and venules to increased mean airway pressure (Pāw̄) in newborn pigs. We further characterized the changes in cortical subarachnoid cerebrospinal fluid prostanoids with increased Pāw̄, both before and afer cyclooxygenase inhibition with indomethacin. Eight chloralose anesthetized newborn pigs were equipped with closed cranial windows and ventilated with a conventional infant pressure-cycled respirator. Increasing Pāw̄ from 3.2 ± 0.3 cm water to 14.3 ± 0.6 cm water did not change pial arteriole or venule diameters. Cerebrospinal fluid prostanoids (6-keto-PGF1α, TxB2, PGE2, and PGE2α), however were increased reversibly (3- to 5-fold) by increasing Pāw̄. After indomethacin (5mg/kg, intravenous) pial arterioles constricted approximately 15% with increased Pāw̄. These results suggest that increasing ventilation pressures increases brain prostanoid production. Prostanoids appear to inhibit vasoconstriction and may be important in maintaining cerebral flow during the stress of mechanical ventilation.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalPediatric Research
Volume22
Issue number6
DOIs
StatePublished - Jan 1 1987

Fingerprint

Prostaglandins
Ventilation
Arterioles
Swine
Pressure
Venules
Dinoprostone
Indomethacin
Cerebrospinal Fluid
Chloralose
Water
Mechanical Ventilators
Prostaglandin-Endoperoxide Synthases
Vasoconstriction
Artificial Respiration
Brain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Increasing ventilation pressure increases cortical subarachnoid cerebrospinall fluid prostanoids in newborn pigs. / Mirro, R.; Armstead, W.; Busija, D.; Green, R.; Leffler, Charles.

In: Pediatric Research, Vol. 22, No. 6, 01.01.1987, p. 647-650.

Research output: Contribution to journalArticle

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