Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning

Einat Levy-Gigi, Szabolcs Kěri, Catherine E. Myers, Zvi Lencovsky, Hadas Sharvit-Benbaji, Scott P. Orr, Mark W. Gilbertson, Richard J. Servatius, Jack Tsao, Mark A. Gluck

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: Drawing on two different populations, Israeli police and Hungarian civilians, the present study assessed the ability of individuals with posttraumatic stress disorder (PTSD) to generalize previous learning to novel situations. Past neuroimaging studies have demonstrated diminished medial temporal lobe (MTL) activation and/or reduced hippocampal volume in individuals with PTSD. Our earlier computational models of cortico-hippocampal function and subsequent experimental tests of these models in MTL-impaired clinical populations argue that even mild hippocampal dysfunction may result in subtle impairments in generalization. Therefore, we predicted that individuals with PTSD would show impaired generalization. Method: We compared the performance of five groups from two countries, including 19 Israeli police with PTSD and 22 traumaexposed police without PTSD, and 22 Hungarian civilians with PTSD, 25 trauma-exposed civilians without PTSD, and 25 individuals without PTSD unexposed to the same trauma. Participants were tested on a two-phase learning paradigm, the Acquired Equivalence Task, which measures the ability to generalize past learning to novel situations. Results: We found that both PTSD and non-PTSD participants were capable of learning the initial stimulus-outcome associations, F(4, 108) = 1.79, p =.14. However, as predicted, only individuals with PTSD showed a selective deficit in generalization of this learning to novel situations (F(4, 108) = 8.35, p <.001, Partial η2 = 0.26). Conclusions: Individuals with PTSD show a selective impairment in generalization of past learning similar to other clinical populations with MTL/hippocampal dysfunction. This is consistent with anemerging view of PTSD as being not only an anxiety disorder but also a learning disorder.

Original languageEnglish (US)
Pages (from-to)758-767
Number of pages10
JournalNeuropsychology
Volume26
Issue number6
DOIs
StatePublished - Dec 1 2012

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Post-Traumatic Stress Disorders
Learning
Police
Temporal Lobe
Aptitude
Population
Learning Disorders
Wounds and Injuries
Anxiety Disorders
Neuroimaging
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology

Cite this

Levy-Gigi, E., Kěri, S., Myers, C. E., Lencovsky, Z., Sharvit-Benbaji, H., Orr, S. P., ... Gluck, M. A. (2012). Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning. Neuropsychology, 26(6), 758-767. https://doi.org/10.1037/a0029361

Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning. / Levy-Gigi, Einat; Kěri, Szabolcs; Myers, Catherine E.; Lencovsky, Zvi; Sharvit-Benbaji, Hadas; Orr, Scott P.; Gilbertson, Mark W.; Servatius, Richard J.; Tsao, Jack; Gluck, Mark A.

In: Neuropsychology, Vol. 26, No. 6, 01.12.2012, p. 758-767.

Research output: Contribution to journalArticle

Levy-Gigi, E, Kěri, S, Myers, CE, Lencovsky, Z, Sharvit-Benbaji, H, Orr, SP, Gilbertson, MW, Servatius, RJ, Tsao, J & Gluck, MA 2012, 'Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning', Neuropsychology, vol. 26, no. 6, pp. 758-767. https://doi.org/10.1037/a0029361
Levy-Gigi E, Kěri S, Myers CE, Lencovsky Z, Sharvit-Benbaji H, Orr SP et al. Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning. Neuropsychology. 2012 Dec 1;26(6):758-767. https://doi.org/10.1037/a0029361
Levy-Gigi, Einat ; Kěri, Szabolcs ; Myers, Catherine E. ; Lencovsky, Zvi ; Sharvit-Benbaji, Hadas ; Orr, Scott P. ; Gilbertson, Mark W. ; Servatius, Richard J. ; Tsao, Jack ; Gluck, Mark A. / Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning. In: Neuropsychology. 2012 ; Vol. 26, No. 6. pp. 758-767.
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