Indole molecules as inhibitors of tubulin polymerization

Potential new anticancer agents

Shivaputra A. Patil, Renukadevi Patil, Duane Miller

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Agents that interfere with tubulin function have a broad anti-tumor spectrum and they represent one of the most significant classes of anticancer agents. In the past few years, several small synthetic molecules that have an indole nucleus as a core structure have been identified as tubulin inhibitors. Among these, several aroylindoles, arylthioindoles, diarylindoles and indolylglyoxyamides have shown good inhibition towards the tubulin polymerization. This article reviews the synthesis, biological activities and SARs of these main classes of indoles. Brief mention has also been made about the fused indole analogs as tubulin inhibitors.

Original languageEnglish (US)
Pages (from-to)2085-2115
Number of pages31
JournalFuture Medicinal Chemistry
Volume4
Issue number16
DOIs
StatePublished - Oct 1 2012

Fingerprint

Tubulin Modulators
Tubulin
Antineoplastic Agents
Indoles
Polymerization
Neoplasms
indole

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

Indole molecules as inhibitors of tubulin polymerization : Potential new anticancer agents. / Patil, Shivaputra A.; Patil, Renukadevi; Miller, Duane.

In: Future Medicinal Chemistry, Vol. 4, No. 16, 01.10.2012, p. 2085-2115.

Research output: Contribution to journalReview article

Patil, Shivaputra A. ; Patil, Renukadevi ; Miller, Duane. / Indole molecules as inhibitors of tubulin polymerization : Potential new anticancer agents. In: Future Medicinal Chemistry. 2012 ; Vol. 4, No. 16. pp. 2085-2115.
@article{ea530e2b59e14854a8e094223d3dbced,
title = "Indole molecules as inhibitors of tubulin polymerization: Potential new anticancer agents",
abstract = "Agents that interfere with tubulin function have a broad anti-tumor spectrum and they represent one of the most significant classes of anticancer agents. In the past few years, several small synthetic molecules that have an indole nucleus as a core structure have been identified as tubulin inhibitors. Among these, several aroylindoles, arylthioindoles, diarylindoles and indolylglyoxyamides have shown good inhibition towards the tubulin polymerization. This article reviews the synthesis, biological activities and SARs of these main classes of indoles. Brief mention has also been made about the fused indole analogs as tubulin inhibitors.",
author = "Patil, {Shivaputra A.} and Renukadevi Patil and Duane Miller",
year = "2012",
month = "10",
day = "1",
doi = "10.4155/fmc.12.141",
language = "English (US)",
volume = "4",
pages = "2085--2115",
journal = "Future Medicinal Chemistry",
issn = "1756-8919",
publisher = "Future Science",
number = "16",

}

TY - JOUR

T1 - Indole molecules as inhibitors of tubulin polymerization

T2 - Potential new anticancer agents

AU - Patil, Shivaputra A.

AU - Patil, Renukadevi

AU - Miller, Duane

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Agents that interfere with tubulin function have a broad anti-tumor spectrum and they represent one of the most significant classes of anticancer agents. In the past few years, several small synthetic molecules that have an indole nucleus as a core structure have been identified as tubulin inhibitors. Among these, several aroylindoles, arylthioindoles, diarylindoles and indolylglyoxyamides have shown good inhibition towards the tubulin polymerization. This article reviews the synthesis, biological activities and SARs of these main classes of indoles. Brief mention has also been made about the fused indole analogs as tubulin inhibitors.

AB - Agents that interfere with tubulin function have a broad anti-tumor spectrum and they represent one of the most significant classes of anticancer agents. In the past few years, several small synthetic molecules that have an indole nucleus as a core structure have been identified as tubulin inhibitors. Among these, several aroylindoles, arylthioindoles, diarylindoles and indolylglyoxyamides have shown good inhibition towards the tubulin polymerization. This article reviews the synthesis, biological activities and SARs of these main classes of indoles. Brief mention has also been made about the fused indole analogs as tubulin inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=84869460356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869460356&partnerID=8YFLogxK

U2 - 10.4155/fmc.12.141

DO - 10.4155/fmc.12.141

M3 - Review article

VL - 4

SP - 2085

EP - 2115

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

SN - 1756-8919

IS - 16

ER -