Indolent Mantle Cell Lymphoma With Nodal Involvement and Mutated Immunoglobulin Heavy Chain Genes

Laurentia Nodit, David W. Bahler, Samuel A. Jacobs, Joseph Locker, Steven H. Swerdlow

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Mantle cell lymphoma (MCL) is typically considered an aggressive but incurable neoplasm composed of cyclin D1+ monoclonal B-cells with a t(11;14)(q13;q32) and usually unmutated immunoglobulin (Ig) genes. Although it has been suggested that a more indolent leukemic disorder exists with the same phenotype and genotype but with mutated Ig genes, others have considered these cases to be variants of chronic lymphocytic leukemia. We present a case of an indolent MCL that was documented with cyclin D1 expression in a lymph node biopsy performed more than 12 years ago. The patient has peripheral blood involvement with a lymphocyte count in the reference range, variable thrombocytopenia, and minimal adenopathy but is otherwise well, never having received any antineoplastic therapy. Study of peripheral blood samples from 2002 revealed a CD5-variable B-cell monoclonal proliferation with a t(11;14)(q13; q32) plus other karyotypic abnormalities, positive fluorescence in situ hybridization studies for the CCND1/IgH translocation, and clonal Ig gene rearrangement with mutated Ig genes (95.7% homology to VH 4-31). The subtle but diagnostic lymph node biopsy in this case helps to further support that an indolent t(11; 14) monoclonal lymphocytosis with mutated Ig genes can represent an MCL variant rather than chronic lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)1030-1034
Number of pages5
JournalHuman pathology
Volume34
Issue number10
DOIs
StatePublished - Jan 1 2003

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Immunoglobulin Heavy Chain Genes
Mantle-Cell Lymphoma
Immunoglobulin Genes
Cyclin D1
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Lymph Nodes
Biopsy
Lymphocytosis
Gene Rearrangement
Lymphocyte Count
Fluorescence In Situ Hybridization
Thrombocytopenia
Antineoplastic Agents
Reference Values
Genotype
Cell Proliferation
Phenotype
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Indolent Mantle Cell Lymphoma With Nodal Involvement and Mutated Immunoglobulin Heavy Chain Genes. / Nodit, Laurentia; Bahler, David W.; Jacobs, Samuel A.; Locker, Joseph; Swerdlow, Steven H.

In: Human pathology, Vol. 34, No. 10, 01.01.2003, p. 1030-1034.

Research output: Contribution to journalArticle

Nodit, Laurentia ; Bahler, David W. ; Jacobs, Samuel A. ; Locker, Joseph ; Swerdlow, Steven H. / Indolent Mantle Cell Lymphoma With Nodal Involvement and Mutated Immunoglobulin Heavy Chain Genes. In: Human pathology. 2003 ; Vol. 34, No. 10. pp. 1030-1034.
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