Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion

R. Winn, Blaine Enderson, S. Price, C. L. Rice

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Goats were divided into three groups and given infusions of live Escherichia coli bacteria. Group I received no treatment, group II was treated with indomethacin (a cyclooxygenase inhibitor), and group III with dazoxiben (a thromboxane synthase inhibitor). Double indicator-dilution extravascular lung water (EVLW) in group I was significantly different from the treated groups. There was an early increase in EVLW in group I and group III but not in group II animals. At 6 h EVLW's in group I, group II, and group III were 100, 45, and 30% above base line, respectively. Lymph flow (Q̇L) and lymph-to-plasma protein ratio (L/P) was not statistically different between groups. Estimated total fluid filtration [Q̇L + d(EVLW)/dt] in group I and III was markedly elevated between 0 and 1.5-2 h after E. coli infusion. Cardiac output (Q̇T) decreased to 40% of base line in group I, and it decreased slightly in group II because of the indomethacin but did not decrease after E. coli. Q̇T decreased in group III but recovered more rapidly than group I. Mean pulmonary arterial pressure increased more rapidly in group I and reached a higher peak than either treated group. At 6 h these groups had similar pulmonary arterial and pulmonary arterial wedge pressures. We conclude that 1) indomethacin but not dazoxiben blocks the early increase in total fluid filtration after bacterial infusion, 2) dazoxiben does not prevent the increased endothelial permeability resulting from infusion of live bacteria, and 3) indomethacin may somewhat ameliorate the endothelial permeability change. Finally, Q̇L and L/P suggest that indomethacin provides no beneficial effect to the lung; however, the opposite conclusion results from EVLW and total fluid filtration measurements.

Original languageEnglish (US)
Pages (from-to)2468-2473
Number of pages6
JournalJournal of Applied Physiology
Volume64
Issue number6
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Extravascular Lung Water
Indomethacin
Escherichia coli
Lung
Lymph
Permeability
Arterial Pressure
Bacteria
Pulmonary Wedge Pressure
Cyclooxygenase Inhibitors
Thromboxanes
Goats
Cardiac Output
Blood Proteins
dazoxiben

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion. / Winn, R.; Enderson, Blaine; Price, S.; Rice, C. L.

In: Journal of Applied Physiology, Vol. 64, No. 6, 01.01.1988, p. 2468-2473.

Research output: Contribution to journalArticle

@article{cbe8d63192644a97986a8a8456665b22,
title = "Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion",
abstract = "Goats were divided into three groups and given infusions of live Escherichia coli bacteria. Group I received no treatment, group II was treated with indomethacin (a cyclooxygenase inhibitor), and group III with dazoxiben (a thromboxane synthase inhibitor). Double indicator-dilution extravascular lung water (EVLW) in group I was significantly different from the treated groups. There was an early increase in EVLW in group I and group III but not in group II animals. At 6 h EVLW's in group I, group II, and group III were 100, 45, and 30{\%} above base line, respectively. Lymph flow (Q̇L) and lymph-to-plasma protein ratio (L/P) was not statistically different between groups. Estimated total fluid filtration [Q̇L + d(EVLW)/dt] in group I and III was markedly elevated between 0 and 1.5-2 h after E. coli infusion. Cardiac output (Q̇T) decreased to 40{\%} of base line in group I, and it decreased slightly in group II because of the indomethacin but did not decrease after E. coli. Q̇T decreased in group III but recovered more rapidly than group I. Mean pulmonary arterial pressure increased more rapidly in group I and reached a higher peak than either treated group. At 6 h these groups had similar pulmonary arterial and pulmonary arterial wedge pressures. We conclude that 1) indomethacin but not dazoxiben blocks the early increase in total fluid filtration after bacterial infusion, 2) dazoxiben does not prevent the increased endothelial permeability resulting from infusion of live bacteria, and 3) indomethacin may somewhat ameliorate the endothelial permeability change. Finally, Q̇L and L/P suggest that indomethacin provides no beneficial effect to the lung; however, the opposite conclusion results from EVLW and total fluid filtration measurements.",
author = "R. Winn and Blaine Enderson and S. Price and Rice, {C. L.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "64",
pages = "2468--2473",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Indomethacin, but not dazoxiben, reduced lung fluid filtration after E. coli infusion

AU - Winn, R.

AU - Enderson, Blaine

AU - Price, S.

AU - Rice, C. L.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Goats were divided into three groups and given infusions of live Escherichia coli bacteria. Group I received no treatment, group II was treated with indomethacin (a cyclooxygenase inhibitor), and group III with dazoxiben (a thromboxane synthase inhibitor). Double indicator-dilution extravascular lung water (EVLW) in group I was significantly different from the treated groups. There was an early increase in EVLW in group I and group III but not in group II animals. At 6 h EVLW's in group I, group II, and group III were 100, 45, and 30% above base line, respectively. Lymph flow (Q̇L) and lymph-to-plasma protein ratio (L/P) was not statistically different between groups. Estimated total fluid filtration [Q̇L + d(EVLW)/dt] in group I and III was markedly elevated between 0 and 1.5-2 h after E. coli infusion. Cardiac output (Q̇T) decreased to 40% of base line in group I, and it decreased slightly in group II because of the indomethacin but did not decrease after E. coli. Q̇T decreased in group III but recovered more rapidly than group I. Mean pulmonary arterial pressure increased more rapidly in group I and reached a higher peak than either treated group. At 6 h these groups had similar pulmonary arterial and pulmonary arterial wedge pressures. We conclude that 1) indomethacin but not dazoxiben blocks the early increase in total fluid filtration after bacterial infusion, 2) dazoxiben does not prevent the increased endothelial permeability resulting from infusion of live bacteria, and 3) indomethacin may somewhat ameliorate the endothelial permeability change. Finally, Q̇L and L/P suggest that indomethacin provides no beneficial effect to the lung; however, the opposite conclusion results from EVLW and total fluid filtration measurements.

AB - Goats were divided into three groups and given infusions of live Escherichia coli bacteria. Group I received no treatment, group II was treated with indomethacin (a cyclooxygenase inhibitor), and group III with dazoxiben (a thromboxane synthase inhibitor). Double indicator-dilution extravascular lung water (EVLW) in group I was significantly different from the treated groups. There was an early increase in EVLW in group I and group III but not in group II animals. At 6 h EVLW's in group I, group II, and group III were 100, 45, and 30% above base line, respectively. Lymph flow (Q̇L) and lymph-to-plasma protein ratio (L/P) was not statistically different between groups. Estimated total fluid filtration [Q̇L + d(EVLW)/dt] in group I and III was markedly elevated between 0 and 1.5-2 h after E. coli infusion. Cardiac output (Q̇T) decreased to 40% of base line in group I, and it decreased slightly in group II because of the indomethacin but did not decrease after E. coli. Q̇T decreased in group III but recovered more rapidly than group I. Mean pulmonary arterial pressure increased more rapidly in group I and reached a higher peak than either treated group. At 6 h these groups had similar pulmonary arterial and pulmonary arterial wedge pressures. We conclude that 1) indomethacin but not dazoxiben blocks the early increase in total fluid filtration after bacterial infusion, 2) dazoxiben does not prevent the increased endothelial permeability resulting from infusion of live bacteria, and 3) indomethacin may somewhat ameliorate the endothelial permeability change. Finally, Q̇L and L/P suggest that indomethacin provides no beneficial effect to the lung; however, the opposite conclusion results from EVLW and total fluid filtration measurements.

UR - http://www.scopus.com/inward/record.url?scp=0023950604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023950604&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 2468

EP - 2473

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -