Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet

Robert S. Green, Charles Leffler, Davis W. Busija, Anthony M. Fletcher, Donathan G. Beasley

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The response of circulating catecholamines to asphyxia in unanesthetized, spontaneously breathing neonatal piglets was measured before and after treatment 1 with indomethacin. Prior to treatment with indomethacin, ı baseline levels [geometric mean, pg/ml (95% confidence limits)] of D, E, and N were 162 (99-266), 174 (52-579), and 380 (286-506), respectively. Inhalation of 10% 02/9% < CO2 for 20 min caused significant increases in arterial levels of all three catecholamines to 389 (230-659, 1514 1 (993-2306), and 3802 (2731-5293), respectively. Treat- 1 ment with indomethacin (5 mg/kg, intravenous) did not significantly alter either baseline levels of the catecholamines or the levels after 20 min of the asphyxiating gas.] In time control piglets, baseline levels and the response to İ asphyxia were similar before and after placebo. These results suggest that the circulating catecholamine response to asphyxia of the neonatal piglet is independent of the prostaglandin system. (Pediatr Res 21: 534-537,1987).

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalPediatric Research
Volume21
Issue number6
DOIs
StatePublished - Jan 1 1987

Fingerprint

Asphyxia
Indomethacin
Catecholamines
Inhalation
Prostaglandins
Respiration
Gases
Placebos
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet. / Green, Robert S.; Leffler, Charles; Busija, Davis W.; Fletcher, Anthony M.; Beasley, Donathan G.

In: Pediatric Research, Vol. 21, No. 6, 01.01.1987, p. 534-537.

Research output: Contribution to journalArticle

Green, Robert S. ; Leffler, Charles ; Busija, Davis W. ; Fletcher, Anthony M. ; Beasley, Donathan G. / Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet. In: Pediatric Research. 1987 ; Vol. 21, No. 6. pp. 534-537.
@article{9f9f186ec50e4bf4a5e04d0f322dcb56,
title = "Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet",
abstract = "The response of circulating catecholamines to asphyxia in unanesthetized, spontaneously breathing neonatal piglets was measured before and after treatment 1 with indomethacin. Prior to treatment with indomethacin, ı baseline levels [geometric mean, pg/ml (95{\%} confidence limits)] of D, E, and N were 162 (99-266), 174 (52-579), and 380 (286-506), respectively. Inhalation of 10{\%} 02/9{\%} < CO2 for 20 min caused significant increases in arterial levels of all three catecholamines to 389 (230-659, 1514 1 (993-2306), and 3802 (2731-5293), respectively. Treat- 1 ment with indomethacin (5 mg/kg, intravenous) did not significantly alter either baseline levels of the catecholamines or the levels after 20 min of the asphyxiating gas.] In time control piglets, baseline levels and the response to İ asphyxia were similar before and after placebo. These results suggest that the circulating catecholamine response to asphyxia of the neonatal piglet is independent of the prostaglandin system. (Pediatr Res 21: 534-537,1987).",
author = "Green, {Robert S.} and Charles Leffler and Busija, {Davis W.} and Fletcher, {Anthony M.} and Beasley, {Donathan G.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1203/00006450-198706000-00005",
language = "English (US)",
volume = "21",
pages = "534--537",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet

AU - Green, Robert S.

AU - Leffler, Charles

AU - Busija, Davis W.

AU - Fletcher, Anthony M.

AU - Beasley, Donathan G.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The response of circulating catecholamines to asphyxia in unanesthetized, spontaneously breathing neonatal piglets was measured before and after treatment 1 with indomethacin. Prior to treatment with indomethacin, ı baseline levels [geometric mean, pg/ml (95% confidence limits)] of D, E, and N were 162 (99-266), 174 (52-579), and 380 (286-506), respectively. Inhalation of 10% 02/9% < CO2 for 20 min caused significant increases in arterial levels of all three catecholamines to 389 (230-659, 1514 1 (993-2306), and 3802 (2731-5293), respectively. Treat- 1 ment with indomethacin (5 mg/kg, intravenous) did not significantly alter either baseline levels of the catecholamines or the levels after 20 min of the asphyxiating gas.] In time control piglets, baseline levels and the response to İ asphyxia were similar before and after placebo. These results suggest that the circulating catecholamine response to asphyxia of the neonatal piglet is independent of the prostaglandin system. (Pediatr Res 21: 534-537,1987).

AB - The response of circulating catecholamines to asphyxia in unanesthetized, spontaneously breathing neonatal piglets was measured before and after treatment 1 with indomethacin. Prior to treatment with indomethacin, ı baseline levels [geometric mean, pg/ml (95% confidence limits)] of D, E, and N were 162 (99-266), 174 (52-579), and 380 (286-506), respectively. Inhalation of 10% 02/9% < CO2 for 20 min caused significant increases in arterial levels of all three catecholamines to 389 (230-659, 1514 1 (993-2306), and 3802 (2731-5293), respectively. Treat- 1 ment with indomethacin (5 mg/kg, intravenous) did not significantly alter either baseline levels of the catecholamines or the levels after 20 min of the asphyxiating gas.] In time control piglets, baseline levels and the response to İ asphyxia were similar before and after placebo. These results suggest that the circulating catecholamine response to asphyxia of the neonatal piglet is independent of the prostaglandin system. (Pediatr Res 21: 534-537,1987).

UR - http://www.scopus.com/inward/record.url?scp=0023181663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023181663&partnerID=8YFLogxK

U2 - 10.1203/00006450-198706000-00005

DO - 10.1203/00006450-198706000-00005

M3 - Article

VL - 21

SP - 534

EP - 537

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 6

ER -