Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment

Arnold Postlethwaite, J. Keski-Oja, G. Balian, Andrew Kang

Research output: Contribution to journalArticle

262 Citations (Scopus)

Abstract

Plasma and cell-derived fibronectin are potent chemoattractants for human dermal fibroblasts in vitro. The chemotactic property of fibronectin resides in a major 140,000-mol wt non-gelatin-binding fragment of the native molecule. Human monocytes and neutrophils do not recognize fibronectin as a chemotactic stimulus. These findings suggest that fibronectin and perhaps certain fragments of fibronectn may function in vivo as a specific chemoattractant for fibroblasts and could, therefore, induce directional migration of fibroblasts to sites of tissue injury, remodeling or morphogenesis.

Original languageEnglish (US)
Pages (from-to)494-499
Number of pages6
JournalJournal of Experimental Medicine
Volume153
Issue number2
DOIs
StatePublished - Jan 1 1981

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Chemotaxis
Fibronectins
Fibroblasts
Molecular Weight
Chemotactic Factors
Plasma Cells
Morphogenesis
Monocytes
Neutrophils
Skin
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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AU - Kang, Andrew

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AB - Plasma and cell-derived fibronectin are potent chemoattractants for human dermal fibroblasts in vitro. The chemotactic property of fibronectin resides in a major 140,000-mol wt non-gelatin-binding fragment of the native molecule. Human monocytes and neutrophils do not recognize fibronectin as a chemotactic stimulus. These findings suggest that fibronectin and perhaps certain fragments of fibronectn may function in vivo as a specific chemoattractant for fibroblasts and could, therefore, induce directional migration of fibroblasts to sites of tissue injury, remodeling or morphogenesis.

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