Induction of fibroblast proliferation by human mononuclear leukocyte‐derived proteins

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Abstract

Human peripheral blood mononuclear leukocytes stimulated by T cell antigen or mitogen release soluble factors that induce mitogenesis of dermal fibroblasts in vitro. Fractionation of supernatants from antigen‐stimulated mononuclear leukocyte cultures by Sephadex G‐100 yielded 2 major peaks of fibroblast proliferation activity (∼60,000 and ∼16,000 MW). Both proliferation factors are heat stable (56°C for 45 minutes) proteins. These data show that mononuclear leukocytes, under appropriate conditions, can release soluble mediators that can stimulate fibroblast proliferation; such leukocytes may also play a role in expanding fibroblast populations adjacent to certain cell‐mediated immune reactions in vivo.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalArthritis and Rheumatism
Volume26
Issue number1
DOIs
StatePublished - 1983

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Mononuclear Leukocytes
Fibroblasts
Proteins
Viral Tumor Antigens
Mitogens
Leukocytes
Hot Temperature
T-Lymphocytes
Skin
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

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abstract = "Human peripheral blood mononuclear leukocytes stimulated by T cell antigen or mitogen release soluble factors that induce mitogenesis of dermal fibroblasts in vitro. Fractionation of supernatants from antigen‐stimulated mononuclear leukocyte cultures by Sephadex G‐100 yielded 2 major peaks of fibroblast proliferation activity (∼60,000 and ∼16,000 MW). Both proliferation factors are heat stable (56°C for 45 minutes) proteins. These data show that mononuclear leukocytes, under appropriate conditions, can release soluble mediators that can stimulate fibroblast proliferation; such leukocytes may also play a role in expanding fibroblast populations adjacent to certain cell‐mediated immune reactions in vivo.",
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AB - Human peripheral blood mononuclear leukocytes stimulated by T cell antigen or mitogen release soluble factors that induce mitogenesis of dermal fibroblasts in vitro. Fractionation of supernatants from antigen‐stimulated mononuclear leukocyte cultures by Sephadex G‐100 yielded 2 major peaks of fibroblast proliferation activity (∼60,000 and ∼16,000 MW). Both proliferation factors are heat stable (56°C for 45 minutes) proteins. These data show that mononuclear leukocytes, under appropriate conditions, can release soluble mediators that can stimulate fibroblast proliferation; such leukocytes may also play a role in expanding fibroblast populations adjacent to certain cell‐mediated immune reactions in vivo.

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