Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response

Patricia S. Pardo, Junaith Mohamed, Michael A. Lopez, Aladin M. Boriek

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Mechanical loading of muscles by intrinsic muscle activity or passive stretch leads to an increase in the production of reactive oxygen species (1, 2). The NAD-dependent protein deacetylase SIRT1 is involved in the protection against oxidative stress by enhancing FOXO-driven Sod2 transcription (3-5). In this report, we unravel a mechanism triggered by mechanical stretch of skeletal muscle cells that leads to an EGR1-dependent transcriptional activation of the Sirt1 gene. The resulting transient increase in SIRT1 expression generates an antioxidative response that contributes to reactive oxygen species scavenging.

Original languageEnglish (US)
Pages (from-to)2559-2566
Number of pages8
JournalJournal of Biological Chemistry
Volume286
Issue number4
DOIs
StatePublished - Jan 28 2011

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Muscle
Reactive Oxygen Species
Skeletal Muscle
Muscles
NAD
Muscle Cells
Transcriptional Activation
Oxidative Stress
Oxidative stress
Scavenging
Transcription
Genes
Chemical activation
Cells
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. / Pardo, Patricia S.; Mohamed, Junaith; Lopez, Michael A.; Boriek, Aladin M.

In: Journal of Biological Chemistry, Vol. 286, No. 4, 28.01.2011, p. 2559-2566.

Research output: Contribution to journalArticle

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