Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

Karl Vass, Michael L. Berger, Thaddeus Nowak, William J. Welch, Hans Lassmann

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

The accumulation of the stress protein HSP70 was found to be an excellent marker for prolonged seizure related metabolic activity of neurons. After kainic acid (KA) induced status epilepticus we observed HSP70 immunoreactivity in the hippocampal CA4 and CA1 sectors, the subiculum, the basolateral and the lateral nuclei of the amygdala, the mediodorsal nucleus of the thalamus, the caudal part of the striatum, the claustrum and in neurons of certain neocortical areas. HSP70-positive nerve cells appeared normal in conventional histological stains. Conversely, degenerating neurons (e.g. in the hippocampal CA3 sector) remained unlabeled.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalNeuroscience Letters
Volume100
Issue number1-3
DOIs
StatePublished - May 22 1989
Externally publishedYes

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Status Epilepticus
Heat-Shock Proteins
Neurons
Hippocampal CA3 Region
Mediodorsal Thalamic Nucleus
Hippocampal CA1 Region
Kainic Acid
Dentate Gyrus
Basal Ganglia
Thalamus
Hippocampus
Seizures
Coloring Agents

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. / Vass, Karl; Berger, Michael L.; Nowak, Thaddeus; Welch, William J.; Lassmann, Hans.

In: Neuroscience Letters, Vol. 100, No. 1-3, 22.05.1989, p. 259-264.

Research output: Contribution to journalArticle

Vass, Karl ; Berger, Michael L. ; Nowak, Thaddeus ; Welch, William J. ; Lassmann, Hans. / Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. In: Neuroscience Letters. 1989 ; Vol. 100, No. 1-3. pp. 259-264.
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