Induction of the allantoin degradative enzymes by allophanic acid, the last intermediate of the pathway

Terrance Cooper, Robert Lawther

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Saccharomyces cerevisiae can utilize allantoin as a sole nitrogen source by degrading it in five steps to ammonia, "CO2", and glyoxylate. We have previously shown that allophanic acid is the inducer of the urea carboxylase: allophanate hydrolase multienzyme complex. Since these enzymes catalyse the last two steps of allantoin degradation, experiments were performed to determine if allophanate was also the inducer of any other enzymes in the pathway. Our data demonstrate that allophanate induces synthesis of at least five of the seven purine degradative enzymes.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume52
Issue number1
DOIs
StatePublished - May 1 1973

Fingerprint

Allantoin
Allophanate Hydrolase
Enzymes
Multienzyme Complexes
Ammonia
Yeast
Saccharomyces cerevisiae
Nitrogen
Degradation
allophanic acid
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Induction of the allantoin degradative enzymes by allophanic acid, the last intermediate of the pathway. / Cooper, Terrance; Lawther, Robert.

In: Biochemical and Biophysical Research Communications, Vol. 52, No. 1, 01.05.1973, p. 137-142.

Research output: Contribution to journalArticle

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