Ineffectiveness of phylloquinone epoxide as an inhibitor of prothrombin synthesis in the rat

Steven Goodman, Robert M. Houser, Robert E. Olson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Phylloquinone epoxide (vitamin K1-oxide), a metabolite of phylloquinone, does not inhibit prothrombin synthesis when administered in high doses to Sprague-Dawley and warfarin-resistant rats. Further, it does not accumulate to presumed inhibitory levels in the livers of rats given physiological doses of 3H-phylloquinone when they are anticoagulated with warfarin. These data do not support the Bell-Matschiner hypothesis that warfarin exerts its action by inhibiting the vitamin K oxide reductase which results in the accumulation of vitamin K oxide and the inhibition of vitamin K at its active site. Rather, our data support the view that vitamin K and warfarin combine at different sites with a single regulatory protein which serves as a conformational switch for prothrombin synthesis.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume61
Issue number1
DOIs
StatePublished - Nov 6 1974
Externally publishedYes

Fingerprint

Vitamin K
Prothrombin
Warfarin
Rats
Vitamin K 1
Oxides
NAD(P)H Dehydrogenase (Quinone)
Metabolites
Liver
Catalytic Domain
Oxidoreductases
Switches
vitamin K1 oxide
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Ineffectiveness of phylloquinone epoxide as an inhibitor of prothrombin synthesis in the rat. / Goodman, Steven; Houser, Robert M.; Olson, Robert E.

In: Biochemical and Biophysical Research Communications, Vol. 61, No. 1, 06.11.1974, p. 250-257.

Research output: Contribution to journalArticle

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