Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: A prospective study

S. Stagno, D. M. Brasfield, M. B. Brown, G. H. Cassell, Linda Pifer, R. J. Whitley, R. E. Tiller

Research output: Contribution to journalArticle

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Abstract

In a prospective study of 104 infants between 1 and 3 months of age hospitalized with pneumonitis, 65 (63%) had evidence of infection with one or more potential respiratory pathogens. Single infections were noted in 48 (74%) whereas mixed infections occurred in 17 (26%) of 65 infected infants. The four most common infections were Chlamydia trachomatis (15/59, 25%), Ureaplasma urealyticum (8/38, 21%), cytomegalovirus (21/104, 20%), and Pneumocystis carinii (19/104, 18%). In sharp contrast, the incidence of these infections in control infants was 0% (0/25), 4% (2/49), 3% (3/97), and 0% (0/64), respectively. The clinical, radiologic, and laboratory characteristics of the pneumonitis syndrome associated with Chlamydia, cytomegalovirus, and Pneumocystis were indistinguishable from each other. Patients with mixed infections had a more severe pneumonitis as measured by the occurrence of apnea and the need of oxygen therapy and mechanical ventilation. The patients enrolled in this study are being followed-up to determine the longitudinal course of these infections.

Original languageEnglish (US)
Pages (from-to)322-329
Number of pages8
JournalPediatrics
Volume68
Issue number3
StatePublished - Nov 30 1981

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Pneumocystis
Ureaplasma
Chlamydia
Cytomegalovirus
Pneumonia
Prospective Studies
Infection
Coinfection
Ureaplasma urealyticum
Pneumocystis carinii
Chlamydia trachomatis
Apnea
Infection Control
Artificial Respiration
Oxygen
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Stagno, S., Brasfield, D. M., Brown, M. B., Cassell, G. H., Pifer, L., Whitley, R. J., & Tiller, R. E. (1981). Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: A prospective study. Pediatrics, 68(3), 322-329.

Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma : A prospective study. / Stagno, S.; Brasfield, D. M.; Brown, M. B.; Cassell, G. H.; Pifer, Linda; Whitley, R. J.; Tiller, R. E.

In: Pediatrics, Vol. 68, No. 3, 30.11.1981, p. 322-329.

Research output: Contribution to journalArticle

Stagno, S, Brasfield, DM, Brown, MB, Cassell, GH, Pifer, L, Whitley, RJ & Tiller, RE 1981, 'Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: A prospective study', Pediatrics, vol. 68, no. 3, pp. 322-329.
Stagno S, Brasfield DM, Brown MB, Cassell GH, Pifer L, Whitley RJ et al. Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: A prospective study. Pediatrics. 1981 Nov 30;68(3):322-329.
Stagno, S. ; Brasfield, D. M. ; Brown, M. B. ; Cassell, G. H. ; Pifer, Linda ; Whitley, R. J. ; Tiller, R. E. / Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma : A prospective study. In: Pediatrics. 1981 ; Vol. 68, No. 3. pp. 322-329.
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