Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries

Miguela A. Caniza, Carla Odio, Sheena Mukkada, Miriam Gonzalez, Francesco Ceppi, Sujittra Chaisavaneeyakorn, Nopporn Apiwattanakul, Scott Howard, Valentino Conter, Miguel Bonilla

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Infections are the most important cause of morbidity and mortality in children treated for acute lymphoblastic leukemia (ALL). The rates of infection-Associated mortality are up to 10-Times higher in low-and middle-income countries (LMIC) than in high-income countries. The prevention, early recognition and management of infectious complications is especially challenging in LMIC because of disease and poverty-related factors, as well as the shortage of trained personnel, supplies, diagnostic tools and adequate organizational infrastructure. Children in LMIC with ALL, who are frequently underweight, are at increased risk of community-Acquired pathogens, nosocomial multidrug-resistant pathogens and opportunistic microorganisms. This review summarizes the challenges of managing the major categories of infections in children receiving treatment for ALL and provides updated practical recommendations for preventing and managing these infections in LMIC.

Original languageEnglish (US)
Pages (from-to)627-645
Number of pages19
JournalExpert Review of Hematology
Volume8
Issue number5
DOIs
StatePublished - Sep 3 2015
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Infection
Child Mortality
Thinness
Poverty
Morbidity
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Caniza, M. A., Odio, C., Mukkada, S., Gonzalez, M., Ceppi, F., Chaisavaneeyakorn, S., ... Bonilla, M. (2015). Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries. Expert Review of Hematology, 8(5), 627-645. https://doi.org/10.1586/17474086.2015.1071186

Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries. / Caniza, Miguela A.; Odio, Carla; Mukkada, Sheena; Gonzalez, Miriam; Ceppi, Francesco; Chaisavaneeyakorn, Sujittra; Apiwattanakul, Nopporn; Howard, Scott; Conter, Valentino; Bonilla, Miguel.

In: Expert Review of Hematology, Vol. 8, No. 5, 03.09.2015, p. 627-645.

Research output: Contribution to journalReview article

Caniza, MA, Odio, C, Mukkada, S, Gonzalez, M, Ceppi, F, Chaisavaneeyakorn, S, Apiwattanakul, N, Howard, S, Conter, V & Bonilla, M 2015, 'Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries', Expert Review of Hematology, vol. 8, no. 5, pp. 627-645. https://doi.org/10.1586/17474086.2015.1071186
Caniza, Miguela A. ; Odio, Carla ; Mukkada, Sheena ; Gonzalez, Miriam ; Ceppi, Francesco ; Chaisavaneeyakorn, Sujittra ; Apiwattanakul, Nopporn ; Howard, Scott ; Conter, Valentino ; Bonilla, Miguel. / Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries. In: Expert Review of Hematology. 2015 ; Vol. 8, No. 5. pp. 627-645.
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