Inflammatory abdominal aortic aneurysm and the associated T-cell reaction

A case study

Jon Lieberman, Jeffrey S. Scheib, Paul Googe, Albert T. Ichiki, Mitchell Goldman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The immune response associated with an inflammatory abdominal aortic aneurysm was studied by determining the phenotypes of lymphocytes in the peripheral blood, the aortic aneurysm wall, and the perianeurysmal tissue. Increased numbers of activated T cells were found in all three areas. After aneurysm repair, peripheral blood analysis demonstrated normalization of the T-cell subsets. These data suggest that inflammatory abdominal aortic aneurysm is associated with a measurable immune response in peripheral blood with elevation of the same subset of inflammatory cells (CD4) as detected in abdominal aortic aneurysm tissue, and the immune response regresses after aneurysm repair.

Original languageEnglish (US)
Pages (from-to)569-572
Number of pages4
JournalJournal of Vascular Surgery
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1992

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Abdominal Aortic Aneurysm
T-Lymphocytes
Aneurysm
Aortic Aneurysm
T-Lymphocyte Subsets
Lymphocytes
Phenotype

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Inflammatory abdominal aortic aneurysm and the associated T-cell reaction : A case study. / Lieberman, Jon; Scheib, Jeffrey S.; Googe, Paul; Ichiki, Albert T.; Goldman, Mitchell.

In: Journal of Vascular Surgery, Vol. 15, No. 3, 01.01.1992, p. 569-572.

Research output: Contribution to journalArticle

Lieberman, Jon ; Scheib, Jeffrey S. ; Googe, Paul ; Ichiki, Albert T. ; Goldman, Mitchell. / Inflammatory abdominal aortic aneurysm and the associated T-cell reaction : A case study. In: Journal of Vascular Surgery. 1992 ; Vol. 15, No. 3. pp. 569-572.
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