Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome

Rishi Sukhija, Ibrahim Fahdi, Luis Garza, Louis Fink, Margaret Scott, Wady Aude, Rebecca Pacheco, Zoran Bursac, April Grant, Jawahar L. Mehta

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) have been shown to be predictors of adverse outcomes in patients with coronary artery disease (CAD). We hypothesized that measurement of inflammatory markers could predict atherosclerotic burden and major adverse cardiac events (MACEs). We prospectively measured hs-CRP, IL-6, and TNF-α in 249 patients who were admitted with acute chest pain and underwent coronary angiography. We analyzed the relation between serum levels of inflammatory markers and angiographic severity of CAD. A follow-up at 6 months was conducted to assess MACEs, defined as a cumulative of myocardial infarction, all-cause death, or coronary revascularization (percutaneous coronary intervention or coronary artery bypass surgery). After adjusting for conventional CAD risk factors (age, gender, diabetes, hypertension, smoking, and hypercholesterolemia), there was no association between inflammatory markers (hs-CRP, IL-6, and TNF-α) and angiographic severity of CAD. There was a significant positive correlation between age, male gender, diabetes mellitus, and hypercholesterolemia with atherosclerotic burden determined by angiography. There was no significant positive association between MACEs and hs-CRP, IL-6, or TNF-α level in unadjusted and adjusted models. In conclusion, in patients hospitalized with chest pain, we found no association of serum levels of hs-CRP, IL-6, or TNF-α with coronary atherosclerotic burden or MACEs at 6 months after adjustment for traditional CAD risk factors.

Original languageEnglish (US)
Pages (from-to)879-884
Number of pages6
JournalAmerican Journal of Cardiology
Volume99
Issue number7
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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C-Reactive Protein
Coronary Artery Disease
Interleukin-6
Tumor Necrosis Factor-alpha
Hypercholesterolemia
Chest Pain
Serum
Acute Pain
Percutaneous Coronary Intervention
Coronary Angiography
Coronary Artery Bypass
Cause of Death
Diabetes Mellitus
Angiography
Smoking
Myocardial Infarction
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Sukhija, R., Fahdi, I., Garza, L., Fink, L., Scott, M., Aude, W., ... Mehta, J. L. (2007). Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome. American Journal of Cardiology, 99(7), 879-884. https://doi.org/10.1016/j.amjcard.2006.11.032

Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome. / Sukhija, Rishi; Fahdi, Ibrahim; Garza, Luis; Fink, Louis; Scott, Margaret; Aude, Wady; Pacheco, Rebecca; Bursac, Zoran; Grant, April; Mehta, Jawahar L.

In: American Journal of Cardiology, Vol. 99, No. 7, 01.04.2007, p. 879-884.

Research output: Contribution to journalArticle

Sukhija, R, Fahdi, I, Garza, L, Fink, L, Scott, M, Aude, W, Pacheco, R, Bursac, Z, Grant, A & Mehta, JL 2007, 'Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome', American Journal of Cardiology, vol. 99, no. 7, pp. 879-884. https://doi.org/10.1016/j.amjcard.2006.11.032
Sukhija, Rishi ; Fahdi, Ibrahim ; Garza, Luis ; Fink, Louis ; Scott, Margaret ; Aude, Wady ; Pacheco, Rebecca ; Bursac, Zoran ; Grant, April ; Mehta, Jawahar L. / Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome. In: American Journal of Cardiology. 2007 ; Vol. 99, No. 7. pp. 879-884.
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