Influence of garlic supplementation on human fecal flora and serum lipid levels

K. Roberts, D. K.W. Jahner, Randal Buddington

Research output: Contribution to journalArticle

Abstract

The effect of garlic supplementation on the intestinal microflora and serum lipid concentrations in healthy humans consuming an uncontrolled diet was examined. For 90 days, subjects (13 men, 7 women; mean age +/- SEM 28 +/- 1.9 years) were given a garlic-based dietary supplement providing 3 grams of dehydrated garlic powder. Garlic supplementation had no effect on fecal bacterial counts. After 90 days of supplementation, a significant reduction in mean serum cholesterol (178 +/- 7.7 mg/dl baseline vs. 164 +/- 7.1 mg/dl day 90, p=.0005) and mean serum low-density lipoprotein (121 +/- 7.3 mg/dl baseline vs. 104 +/- 6.0 mg/dl day 90, p=.0009) concentrations were observed. The mean total cholesterol to high-density lipoprotein cholesterol ratio was also significantly reduced, evident after the first 30 days of supplementation (5.2 +/-0.5 baseline vs. 4.7 +/- 0.5 and 4.6 +/- 0.5 on days 30 and 90 respectively, p=.0227 and .0003). This data suggest that garlic supplementation has the potential to positively affect circulating lipids in humans, and in this way, may help in the prevention of cardiovascular risk.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

Garlic
garlic
blood lipids
Dietary supplements
flora
Cholesterol
Lipids
Nutrition
Serum
LDL Lipoproteins
Powders
HDL Cholesterol
Scanning electron microscopy
cholesterol
Bacterial Load
low density lipoprotein
Dietary Supplements
intestinal microorganisms
high density lipoprotein cholesterol
plate count

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Influence of garlic supplementation on human fecal flora and serum lipid levels. / Roberts, K.; Jahner, D. K.W.; Buddington, Randal.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

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