Influence of Intraarterial Norepinephrine on Cerebral Hemodynamics of Newborn Pigs

Alfred H. Rogers, William M. Armstead, Robert Mirro, David W. Busija, Charles Leffler

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Effects of intraarterial norepinephrine on cerebral hemodynamics were investigated in conscious newborn pigs. Intracarotid infusion of norepinephrine (100 ng/min) increased cerebral blood flow from 72 ± 5 to 82 ± 8 ml/100 g·min. The norepinephrine-induced increase in cerebral blood flow was accompanied by an increase in cerebral oxygen consumption from 2.75 ± 0.17 to 3.11 ± 0.29 ml O2/100 g·min. Both the increase in cerebral oxygen consumption and the increase in cerebral blood flow were blocked by propranolol and unchanged by combined prazosin and yohimbine treatment. These data show that intraarterial norepinephrine increases cerebral blood flow and cerebral oxygen consumption in newborn pigs. β-Adrenergic stimulation increases cerebral oxygen consumption. This increase may produce the increase in cerebral blood flow caused by the norepinephrine.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume191
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Cerebrovascular Circulation
Hemodynamics
Norepinephrine
Blood
Swine
Oxygen Consumption
Oxygen
Yohimbine
Prazosin
Propranolol
Adrenergic Agents

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Influence of Intraarterial Norepinephrine on Cerebral Hemodynamics of Newborn Pigs. / Rogers, Alfred H.; Armstead, William M.; Mirro, Robert; Busija, David W.; Leffler, Charles.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 191, No. 2, 01.01.1989, p. 174-178.

Research output: Contribution to journalArticle

Rogers, Alfred H. ; Armstead, William M. ; Mirro, Robert ; Busija, David W. ; Leffler, Charles. / Influence of Intraarterial Norepinephrine on Cerebral Hemodynamics of Newborn Pigs. In: Proceedings of the Society for Experimental Biology and Medicine. 1989 ; Vol. 191, No. 2. pp. 174-178.
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