Influence of opioids on CSF vasopressin concentration in newborn pigs

W. M. Armstead, J. T. Crofton, L. Share, R. Mirro, S. L. Zuckerman, Charles Leffler

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to determine the influence of opioids on periarachnoid cortical cerebrospinal fluid (CSF) vasopressin concentration in newborn pigs equipped with closed cranial windows. Topical dynorphin-(1-13) produced tone-dependent pial arterial responses (dilation during normotension, constriction when cerebrovascular tone was decreased by hypotension). Dynorphin-(1-13) increased periarachnoid cortical CSF vasopressin concentrations in both normotensive and hypotensive piglets (5 ± 1, 11 ± 1, and 233 ± 27 μU/ml for control, 10 -10, and 10-6 M dynorphin-(1-13) during normotension, respectively). Dynorphin-(1-8) and U 50488H, a purported selective κ- opioid receptor agonist, produced similar tone-dependent responses associated with smaller increases in CSF vasopressin concentration. β-Endorphin caused only cerebral vasoconstriction associated with modest increases in CSF vasopressin (3 ± 1, 5 ± 1, 9 ± 2 μU/ml for control, 10-10, and 10-6 M β-endorphin, respectively). In contrast, methionine enkephalin- and leucine enkephalin-induced dilations were not associated with changes in CSF vasopressin concentration. Naloxone (1 mg/kg iv) blocked both the opioid-induced vascular effects and associated changes in CSF vasopressin concentration. Naloxone also attenuated the increase in CSF vasopressin concentration in response to hemorrhagic hypotension. These data show that dynorphin- and β-endorphin-induced cerebrovascular effects are associated with increased CSF vasopressin concentration. Furthermore, these data indicate that opioids could contribute to the increase in CSF vasopressin concentration observed in response to hemorrhagic hypotension.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume262
Issue number3 31-3
StatePublished - Jan 1 1992

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Vasopressins
Opioid Analgesics
Cerebrospinal Fluid
Swine
Endorphins
Hypotension
dynorphin (1-8)
Naloxone
Dilatation
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
Leucine Enkephalin
Dynorphins
Methionine Enkephalin
Opioid Receptors
Vasoconstriction
Constriction
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Influence of opioids on CSF vasopressin concentration in newborn pigs. / Armstead, W. M.; Crofton, J. T.; Share, L.; Mirro, R.; Zuckerman, S. L.; Leffler, Charles.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 262, No. 3 31-3, 01.01.1992.

Research output: Contribution to journalArticle

Armstead, W. M. ; Crofton, J. T. ; Share, L. ; Mirro, R. ; Zuckerman, S. L. ; Leffler, Charles. / Influence of opioids on CSF vasopressin concentration in newborn pigs. In: American Journal of Physiology - Heart and Circulatory Physiology. 1992 ; Vol. 262, No. 3 31-3.
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