Influence of vasoactive intestinal contractor on the feline pulmonary vascular bed

Philip J. Kadowitz, Peter Kvamme, Bobby D. Nossaman, Ikhlass N. Ibrahim, Robert K. Minkes

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pulmonary vascular responses to vasoactive intestinal contractor (VIC) (endothelin-B) were investigated in the feline pulmonary vascular bed under constant and natural flow conditions. Injection of VIC, 0.3 nmol/kg i.v., increased pulmonary arterial and left atrial pressures and cardiac output and caused a biphasic change in pulmonary vascular resistance. VIC and endothelin-1 (ET-1) caused a similar pattern of response and under constant flow conditions, VIC increased lobar arterial pressure in a dose-related manner and was similar in potency and duration of action to ET-1. The thromboxane mimic, U46619, was far more potent than VIC, and a monocyclic ET-analog had no activity in the pulmonary vascular bed. The present data show that VIC has significant vasoconstrictor activity in the pulmonary vascular bed of the cat.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalEuropean Journal of Pharmacology
Volume194
Issue number1
DOIs
StatePublished - Feb 26 1991
Externally publishedYes

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Felidae
Blood Vessels
Lung
Endothelin-1
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Atrial Pressure
Thromboxanes
Endothelins
Vasoconstrictor Agents
Cardiac Output
Vascular Resistance
vasoactive intestinal constrictor
Arterial Pressure
Cats
Injections

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Influence of vasoactive intestinal contractor on the feline pulmonary vascular bed. / Kadowitz, Philip J.; Kvamme, Peter; Nossaman, Bobby D.; Ibrahim, Ikhlass N.; Minkes, Robert K.

In: European Journal of Pharmacology, Vol. 194, No. 1, 26.02.1991, p. 127-130.

Research output: Contribution to journalArticle

Kadowitz, Philip J. ; Kvamme, Peter ; Nossaman, Bobby D. ; Ibrahim, Ikhlass N. ; Minkes, Robert K. / Influence of vasoactive intestinal contractor on the feline pulmonary vascular bed. In: European Journal of Pharmacology. 1991 ; Vol. 194, No. 1. pp. 127-130.
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