Influenza A virus infection kinetics: Quantitative data and models

Amber Smith, Alan S. Perelson

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Influenza A virus is an important respiratory pathogen that poses a considerable threat to public health each year during seasonal epidemics and even more so when a pandemic strain emerges. Understanding the mechanisms involved in controlling an influenza infection within a host is important and could result in new and effective treatment strategies. Kinetic models of influenza viral growth and decay can summarize data and evaluate the biological parameters governing interactions between the virus and the host. Here we discuss recent viral kinetic models for influenza. We show how these models have been used to provide insight into influenza pathogenesis and treatment, and we highlight the challenges of viral kinetic analysis, including accurate model formulation, estimation of important parameters, and the collection of detailed data sets thatmeasuremultiple variables simultaneously.

Original languageEnglish (US)
Pages (from-to)429-445
Number of pages17
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2011

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Influenza A virus
Virus Diseases
Viruses
Human Influenza
Kinetics
Pandemics
Public health
Pathogens
Public Health
Growth
Infection

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Influenza A virus infection kinetics : Quantitative data and models. / Smith, Amber; Perelson, Alan S.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 3, No. 4, 01.07.2011, p. 429-445.

Research output: Contribution to journalReview article

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