Influenza B virus encephalitis

Jonathan Mccullers, S. Facchini, P. J. Chesney, R. G. Webster

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Acute encephalitis and postinfectious encephalopathy have been reported infrequently in association with influenza A and B virus infections. We report herein a case of a 6-year-old girl with acute influenza B virus encephalitis resulting in neurological sequelae. The diagnosis was made by isolation of influenza B virus from the nasopharynx, seroconversion to influenza B, and reverse transcription polymerase chain reaction (RT-PCR) identification of the virus from the patient's cerebrospinal fluid. Direct sequencing of vital RNA from the patient's nasopharynx and cerebrospinal fluid revealed identical nucleotide sequences in the HA1 region of the hemagglutinin gene. This is the first report of influenza B virus encephalitis diagnosed by use of RT-PCR and illustrates the need for increased awareness of influenza virus as a cause of acute encephalitis. PCR may be a useful tool for diagnosing future cases.

Original languageEnglish (US)
Pages (from-to)898-900
Number of pages3
JournalClinical Infectious Diseases
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1999

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Influenza B virus
Encephalitis
Nasopharynx
Polymerase Chain Reaction
Reverse Transcription
Cerebrospinal Fluid
RNA Sequence Analysis
Influenza A virus
Hemagglutinins
Brain Diseases
Virus Diseases
Orthomyxoviridae
Human Influenza
Viruses
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mccullers, J., Facchini, S., Chesney, P. J., & Webster, R. G. (1999). Influenza B virus encephalitis. Clinical Infectious Diseases, 28(4), 898-900. https://doi.org/10.1086/515214

Influenza B virus encephalitis. / Mccullers, Jonathan; Facchini, S.; Chesney, P. J.; Webster, R. G.

In: Clinical Infectious Diseases, Vol. 28, No. 4, 01.01.1999, p. 898-900.

Research output: Contribution to journalArticle

Mccullers, J, Facchini, S, Chesney, PJ & Webster, RG 1999, 'Influenza B virus encephalitis', Clinical Infectious Diseases, vol. 28, no. 4, pp. 898-900. https://doi.org/10.1086/515214
Mccullers J, Facchini S, Chesney PJ, Webster RG. Influenza B virus encephalitis. Clinical Infectious Diseases. 1999 Jan 1;28(4):898-900. https://doi.org/10.1086/515214
Mccullers, Jonathan ; Facchini, S. ; Chesney, P. J. ; Webster, R. G. / Influenza B virus encephalitis. In: Clinical Infectious Diseases. 1999 ; Vol. 28, No. 4. pp. 898-900.
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