Informatics Center for Mouse Genomics: The Dissection of Complex Traits of the Nervous System

Glenn D. Rosen, Nathan T. La Porte, Boris Diechtiareff, Christopher J. Pung, Jonathan Nissanov, Carl Gustafson, Louise Bertrand, Smadar Gefen, Yingli Fan, Oleh J. Tretiak, Kenneth F. Manly, Melburn R. Park, Alexander G. Williams, Michael T. Connolly, John A. Capra, Robert Williams

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS) development and function. Here, we exploit a powerful new reductionist approach to explore the genetic basis of the very significant structural and molecular differences between the brains of different strains of mice, called either complex trait or quantitative trait loci (QTL) analysis. Our specific focus has been to provide universal access over the web to tools for the genetic dissection of complex traits of the CNS-tools that allow researchers to map genes that modulate phenotypes at a variety of levels ranging from the molecular all the way to the anatomy of the entire brain. Our website, The Mouse Brain Library (MBL; http://mbl.org) is comprised of four interrelated components that are designed to support this goal: The Brain Library, iScope, Neurocartographer, and WebQTL. The centerpiece of the MBL is an image database of histologically prepared museum-quality slides representing nearly 2000 mice from over 120 strains-a library suitable for stereologic analysis of regional volume. The iScope provides fast access to the entire slide collection using streaming video technology, enabling neuroscientists to acquire high-magnification images of any CNS region for any of the mice in the MBL. Neurocartographer provides automatic segmentation of images from the MBL by warping precisely delineated boundaries from a 3D atlas of the mouse brain. Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes.

Original languageEnglish (US)
Pages (from-to)327-342
Number of pages16
JournalNeuroinformatics
Volume1
Issue number4
DOIs
StatePublished - Nov 11 2003

Fingerprint

Dissection
Informatics
Neurology
Genomics
Nervous System
Brain
Central Nervous System
Webcasts
Research Personnel
Phenotype
Museums
Explosions
Atlases
Video streaming
Quantitative Trait Loci
Libraries
Websites
Anatomy
Genes
Genotype

All Science Journal Classification (ASJC) codes

  • Software
  • Neuroscience(all)
  • Information Systems

Cite this

Rosen, G. D., La Porte, N. T., Diechtiareff, B., Pung, C. J., Nissanov, J., Gustafson, C., ... Williams, R. (2003). Informatics Center for Mouse Genomics: The Dissection of Complex Traits of the Nervous System. Neuroinformatics, 1(4), 327-342. https://doi.org/10.1385/NI:1:4:327

Informatics Center for Mouse Genomics : The Dissection of Complex Traits of the Nervous System. / Rosen, Glenn D.; La Porte, Nathan T.; Diechtiareff, Boris; Pung, Christopher J.; Nissanov, Jonathan; Gustafson, Carl; Bertrand, Louise; Gefen, Smadar; Fan, Yingli; Tretiak, Oleh J.; Manly, Kenneth F.; Park, Melburn R.; Williams, Alexander G.; Connolly, Michael T.; Capra, John A.; Williams, Robert.

In: Neuroinformatics, Vol. 1, No. 4, 11.11.2003, p. 327-342.

Research output: Contribution to journalArticle

Rosen, GD, La Porte, NT, Diechtiareff, B, Pung, CJ, Nissanov, J, Gustafson, C, Bertrand, L, Gefen, S, Fan, Y, Tretiak, OJ, Manly, KF, Park, MR, Williams, AG, Connolly, MT, Capra, JA & Williams, R 2003, 'Informatics Center for Mouse Genomics: The Dissection of Complex Traits of the Nervous System', Neuroinformatics, vol. 1, no. 4, pp. 327-342. https://doi.org/10.1385/NI:1:4:327
Rosen GD, La Porte NT, Diechtiareff B, Pung CJ, Nissanov J, Gustafson C et al. Informatics Center for Mouse Genomics: The Dissection of Complex Traits of the Nervous System. Neuroinformatics. 2003 Nov 11;1(4):327-342. https://doi.org/10.1385/NI:1:4:327
Rosen, Glenn D. ; La Porte, Nathan T. ; Diechtiareff, Boris ; Pung, Christopher J. ; Nissanov, Jonathan ; Gustafson, Carl ; Bertrand, Louise ; Gefen, Smadar ; Fan, Yingli ; Tretiak, Oleh J. ; Manly, Kenneth F. ; Park, Melburn R. ; Williams, Alexander G. ; Connolly, Michael T. ; Capra, John A. ; Williams, Robert. / Informatics Center for Mouse Genomics : The Dissection of Complex Traits of the Nervous System. In: Neuroinformatics. 2003 ; Vol. 1, No. 4. pp. 327-342.
@article{dde1bafe15564d309cd455f08ed6a526,
title = "Informatics Center for Mouse Genomics: The Dissection of Complex Traits of the Nervous System",
abstract = "In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS) development and function. Here, we exploit a powerful new reductionist approach to explore the genetic basis of the very significant structural and molecular differences between the brains of different strains of mice, called either complex trait or quantitative trait loci (QTL) analysis. Our specific focus has been to provide universal access over the web to tools for the genetic dissection of complex traits of the CNS-tools that allow researchers to map genes that modulate phenotypes at a variety of levels ranging from the molecular all the way to the anatomy of the entire brain. Our website, The Mouse Brain Library (MBL; http://mbl.org) is comprised of four interrelated components that are designed to support this goal: The Brain Library, iScope, Neurocartographer, and WebQTL. The centerpiece of the MBL is an image database of histologically prepared museum-quality slides representing nearly 2000 mice from over 120 strains-a library suitable for stereologic analysis of regional volume. The iScope provides fast access to the entire slide collection using streaming video technology, enabling neuroscientists to acquire high-magnification images of any CNS region for any of the mice in the MBL. Neurocartographer provides automatic segmentation of images from the MBL by warping precisely delineated boundaries from a 3D atlas of the mouse brain. Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes.",
author = "Rosen, {Glenn D.} and {La Porte}, {Nathan T.} and Boris Diechtiareff and Pung, {Christopher J.} and Jonathan Nissanov and Carl Gustafson and Louise Bertrand and Smadar Gefen and Yingli Fan and Tretiak, {Oleh J.} and Manly, {Kenneth F.} and Park, {Melburn R.} and Williams, {Alexander G.} and Connolly, {Michael T.} and Capra, {John A.} and Robert Williams",
year = "2003",
month = "11",
day = "11",
doi = "10.1385/NI:1:4:327",
language = "English (US)",
volume = "1",
pages = "327--342",
journal = "Neuroinformatics",
issn = "1539-2791",
publisher = "Humana Press",
number = "4",

}

TY - JOUR

T1 - Informatics Center for Mouse Genomics

T2 - The Dissection of Complex Traits of the Nervous System

AU - Rosen, Glenn D.

AU - La Porte, Nathan T.

AU - Diechtiareff, Boris

AU - Pung, Christopher J.

AU - Nissanov, Jonathan

AU - Gustafson, Carl

AU - Bertrand, Louise

AU - Gefen, Smadar

AU - Fan, Yingli

AU - Tretiak, Oleh J.

AU - Manly, Kenneth F.

AU - Park, Melburn R.

AU - Williams, Alexander G.

AU - Connolly, Michael T.

AU - Capra, John A.

AU - Williams, Robert

PY - 2003/11/11

Y1 - 2003/11/11

N2 - In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS) development and function. Here, we exploit a powerful new reductionist approach to explore the genetic basis of the very significant structural and molecular differences between the brains of different strains of mice, called either complex trait or quantitative trait loci (QTL) analysis. Our specific focus has been to provide universal access over the web to tools for the genetic dissection of complex traits of the CNS-tools that allow researchers to map genes that modulate phenotypes at a variety of levels ranging from the molecular all the way to the anatomy of the entire brain. Our website, The Mouse Brain Library (MBL; http://mbl.org) is comprised of four interrelated components that are designed to support this goal: The Brain Library, iScope, Neurocartographer, and WebQTL. The centerpiece of the MBL is an image database of histologically prepared museum-quality slides representing nearly 2000 mice from over 120 strains-a library suitable for stereologic analysis of regional volume. The iScope provides fast access to the entire slide collection using streaming video technology, enabling neuroscientists to acquire high-magnification images of any CNS region for any of the mice in the MBL. Neurocartographer provides automatic segmentation of images from the MBL by warping precisely delineated boundaries from a 3D atlas of the mouse brain. Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes.

AB - In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS) development and function. Here, we exploit a powerful new reductionist approach to explore the genetic basis of the very significant structural and molecular differences between the brains of different strains of mice, called either complex trait or quantitative trait loci (QTL) analysis. Our specific focus has been to provide universal access over the web to tools for the genetic dissection of complex traits of the CNS-tools that allow researchers to map genes that modulate phenotypes at a variety of levels ranging from the molecular all the way to the anatomy of the entire brain. Our website, The Mouse Brain Library (MBL; http://mbl.org) is comprised of four interrelated components that are designed to support this goal: The Brain Library, iScope, Neurocartographer, and WebQTL. The centerpiece of the MBL is an image database of histologically prepared museum-quality slides representing nearly 2000 mice from over 120 strains-a library suitable for stereologic analysis of regional volume. The iScope provides fast access to the entire slide collection using streaming video technology, enabling neuroscientists to acquire high-magnification images of any CNS region for any of the mice in the MBL. Neurocartographer provides automatic segmentation of images from the MBL by warping precisely delineated boundaries from a 3D atlas of the mouse brain. Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes.

UR - http://www.scopus.com/inward/record.url?scp=10744227038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744227038&partnerID=8YFLogxK

U2 - 10.1385/NI:1:4:327

DO - 10.1385/NI:1:4:327

M3 - Article

C2 - 15043219

AN - SCOPUS:10744227038

VL - 1

SP - 327

EP - 342

JO - Neuroinformatics

JF - Neuroinformatics

SN - 1539-2791

IS - 4

ER -