Inhalation therapy with metered-dose inhalers and dry powder inhalers in mechanically ventilated patients

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Pressurized metered-dose inhalers (pMDIs) are commonly employed for administering bronchodilator aerosols to mechanically ventilated patients. Although it is feasible to employ dry powder inhalers in ventilator circuits, the presence of humidity in the ventilator circuit could reduce their efficiency. A complex array of factors influence drug delivery from pMDIs during mechanical ventilation, and subtle differences in the method of administration can markedly alter aerosol deposition in the lower respiratory tract. However, when the technique of administration is optimized, the efficiency of drug delivery from pMDIs in mechanically ventilated patients is comparable to that in ambulatory patients. Significant bronchodilator effects are observed with as few as 4 puffs from a pMDI and cylindrical spacer. In mechanically ventilated patients, pMDIs are a cost-effective, convenient, and safe method for delivering bronchodilator aerosols.

Original languageEnglish (US)
Pages (from-to)1331-1344
Number of pages14
JournalRespiratory Care
Volume50
Issue number10
StatePublished - Oct 1 2005
Externally publishedYes

Fingerprint

Dry Powder Inhalers
Metered Dose Inhalers
Respiratory Therapy
Bronchodilator Agents
Aerosols
Mechanical Ventilators
Humidity
Artificial Respiration
Pharmaceutical Preparations
Respiratory System
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Inhalation therapy with metered-dose inhalers and dry powder inhalers in mechanically ventilated patients. / Dhand, Rajiv.

In: Respiratory Care, Vol. 50, No. 10, 01.10.2005, p. 1331-1344.

Research output: Contribution to journalArticle

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