Inherited thrombophilia

Haley M. Phillippe, Lori B. Hornsby, Sarah Eudaley, Emily M. Armstrong, Jessica M. Bellone

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI). Although FVL and prothrombin mutation are common disorders, deficiencies in the natural anticoagulants are rare. The risk of initial thrombosis conferred by inherited thrombophilia varies with the highest risk in those homozygous for either FVL or prothrombin mutation, or with AT deficiency. In the nonpregnant patient, the presence of a thrombophilia does not affect treatment of an acute event. Although vitamin B supplementation has been shown to decrease the levels of homocysteine, the treatment has failed to show a benefit in thrombus prevention and is therefore not recommended.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalJournal of Pharmacy Practice
Volume27
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Thrombophilia
Prothrombin
Thrombosis
Anticoagulants
Mutation
Factor XI
Antithrombin Proteins
Vitamin B Complex
Hyperhomocysteinemia
Blood Coagulation Factors
Antithrombins
Protein S
Factor VIII
Homocysteine
Protein C
Hemostasis
Therapeutics
factor V Leiden

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Phillippe, H. M., Hornsby, L. B., Eudaley, S., Armstrong, E. M., & Bellone, J. M. (2014). Inherited thrombophilia. Journal of Pharmacy Practice, 27(3), 227-233. https://doi.org/10.1177/0897190014530390

Inherited thrombophilia. / Phillippe, Haley M.; Hornsby, Lori B.; Eudaley, Sarah; Armstrong, Emily M.; Bellone, Jessica M.

In: Journal of Pharmacy Practice, Vol. 27, No. 3, 01.01.2014, p. 227-233.

Research output: Contribution to journalArticle

Phillippe, HM, Hornsby, LB, Eudaley, S, Armstrong, EM & Bellone, JM 2014, 'Inherited thrombophilia', Journal of Pharmacy Practice, vol. 27, no. 3, pp. 227-233. https://doi.org/10.1177/0897190014530390
Phillippe HM, Hornsby LB, Eudaley S, Armstrong EM, Bellone JM. Inherited thrombophilia. Journal of Pharmacy Practice. 2014 Jan 1;27(3):227-233. https://doi.org/10.1177/0897190014530390
Phillippe, Haley M. ; Hornsby, Lori B. ; Eudaley, Sarah ; Armstrong, Emily M. ; Bellone, Jessica M. / Inherited thrombophilia. In: Journal of Pharmacy Practice. 2014 ; Vol. 27, No. 3. pp. 227-233.
@article{bba7d2bec6554003b7bbe80686204b3e,
title = "Inherited thrombophilia",
abstract = "Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI). Although FVL and prothrombin mutation are common disorders, deficiencies in the natural anticoagulants are rare. The risk of initial thrombosis conferred by inherited thrombophilia varies with the highest risk in those homozygous for either FVL or prothrombin mutation, or with AT deficiency. In the nonpregnant patient, the presence of a thrombophilia does not affect treatment of an acute event. Although vitamin B supplementation has been shown to decrease the levels of homocysteine, the treatment has failed to show a benefit in thrombus prevention and is therefore not recommended.",
author = "Phillippe, {Haley M.} and Hornsby, {Lori B.} and Sarah Eudaley and Armstrong, {Emily M.} and Bellone, {Jessica M.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1177/0897190014530390",
language = "English (US)",
volume = "27",
pages = "227--233",
journal = "Journal of Pharmacy Practice",
issn = "0897-1900",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Inherited thrombophilia

AU - Phillippe, Haley M.

AU - Hornsby, Lori B.

AU - Eudaley, Sarah

AU - Armstrong, Emily M.

AU - Bellone, Jessica M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI). Although FVL and prothrombin mutation are common disorders, deficiencies in the natural anticoagulants are rare. The risk of initial thrombosis conferred by inherited thrombophilia varies with the highest risk in those homozygous for either FVL or prothrombin mutation, or with AT deficiency. In the nonpregnant patient, the presence of a thrombophilia does not affect treatment of an acute event. Although vitamin B supplementation has been shown to decrease the levels of homocysteine, the treatment has failed to show a benefit in thrombus prevention and is therefore not recommended.

AB - Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI). Although FVL and prothrombin mutation are common disorders, deficiencies in the natural anticoagulants are rare. The risk of initial thrombosis conferred by inherited thrombophilia varies with the highest risk in those homozygous for either FVL or prothrombin mutation, or with AT deficiency. In the nonpregnant patient, the presence of a thrombophilia does not affect treatment of an acute event. Although vitamin B supplementation has been shown to decrease the levels of homocysteine, the treatment has failed to show a benefit in thrombus prevention and is therefore not recommended.

UR - http://www.scopus.com/inward/record.url?scp=84904717762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904717762&partnerID=8YFLogxK

U2 - 10.1177/0897190014530390

DO - 10.1177/0897190014530390

M3 - Article

VL - 27

SP - 227

EP - 233

JO - Journal of Pharmacy Practice

JF - Journal of Pharmacy Practice

SN - 0897-1900

IS - 3

ER -