Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

Translated title of the contribution: Inhibition of cathepsin G and elastase from human granulocytes by multiple forms of the Bowman-Birk type of soy inhibitor

N. I. Larionova, I. P. Gladysheva, T. V. Tikhonova, N. F. Kazanskaia

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

Original languageRussian
Pages (from-to)1437-1444
Number of pages8
JournalBiokhimiya
Volume58
Issue number9
StatePublished - Aug 1 1993

Fingerprint

Cathepsin G
Leukocyte Elastase
Pancreatic Elastase
Molecular mass
Glycine
Protein Isoforms
Molecular weight

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Larionova, N. I., Gladysheva, I. P., Tikhonova, T. V., & Kazanskaia, N. F. (1993). Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk. Biokhimiya, 58(9), 1437-1444.

Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk. / Larionova, N. I.; Gladysheva, I. P.; Tikhonova, T. V.; Kazanskaia, N. F.

In: Biokhimiya, Vol. 58, No. 9, 01.08.1993, p. 1437-1444.

Research output: Contribution to journalArticle

Larionova, NI, Gladysheva, IP, Tikhonova, TV & Kazanskaia, NF 1993, 'Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.', Biokhimiya, vol. 58, no. 9, pp. 1437-1444.
Larionova, N. I. ; Gladysheva, I. P. ; Tikhonova, T. V. ; Kazanskaia, N. F. / Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk. In: Biokhimiya. 1993 ; Vol. 58, No. 9. pp. 1437-1444.
@article{60f5ca25f3434bc188f20df82bc5ca5a,
title = "Ingibirovanie katepsina G i {\'e}lastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.",
abstract = "A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.",
author = "Larionova, {N. I.} and Gladysheva, {I. P.} and Tikhonova, {T. V.} and Kazanskaia, {N. F.}",
year = "1993",
month = "8",
day = "1",
language = "Russian",
volume = "58",
pages = "1437--1444",
journal = "Biokhimiia (Moscow, Russia)",
issn = "0320-9725",
publisher = "Izdatel'stvo Nauka",
number = "9",

}

TY - JOUR

T1 - Ingibirovanie katepsina G i élastazy granulotsitov cheloveka mnozhestvennymi formami soevogo ingibitora tipa Baumana-Birk.

AU - Larionova, N. I.

AU - Gladysheva, I. P.

AU - Tikhonova, T. V.

AU - Kazanskaia, N. F.

PY - 1993/8/1

Y1 - 1993/8/1

N2 - A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

AB - A classical soybean inhibitor (Bowman-Birk inhibitor, BBI 2-IV) and two high molecular weight glycine-enriched inhibitors of the same type (3-II and 4-II) have been isolated, purified to homogeneity and characterized. All of the BBI isoforms have been found to effectively inhibit cathepsin G and human granulocyte elastase. The constants for leucocyte cathepsin G inhibition by classical BBI 2-IV (Ki = 1.2 x 10(-9) M) and high molecular mass BBI 3-II (Ki = 8.0 x 10(-8) M) as well as for leucocyte elastase inhibition by high molecular mass BBI 3-II (Ki = 1.1 x 10(-7) M) have been determined.

UR - http://www.scopus.com/inward/record.url?scp=0027645257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027645257&partnerID=8YFLogxK

M3 - Article

VL - 58

SP - 1437

EP - 1444

JO - Biokhimiia (Moscow, Russia)

JF - Biokhimiia (Moscow, Russia)

SN - 0320-9725

IS - 9

ER -