Inhibitory effects of pentamidine analogues on spermine stimulated ligand binding to the NMDA receptor complex

Isaac Donkor, M. L. Berger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

SAR studies of butamidine derivatives with the NMDA receptor complex revealed that hydrophobic rather than hydrophilic linkers between the amidinophenyl groups promote NMDA antagonism. Conformation of the linker did not influence binding in the absence of bis-methoxy substituens ortho to the linker. Like pentamidine, the compounds are noncompetitive NMDA receptor antagonists.

Original languageEnglish (US)
Pages (from-to)1455-1460
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number11
DOIs
StatePublished - Jun 3 1997

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Pentamidine
Spermine
N-Methyl-D-Aspartate Receptors
Ligands
N-Methylaspartate
Conformations
Derivatives
butamidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Inhibitory effects of pentamidine analogues on spermine stimulated ligand binding to the NMDA receptor complex. / Donkor, Isaac; Berger, M. L.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 11, 03.06.1997, p. 1455-1460.

Research output: Contribution to journalArticle

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