Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children

Christian J. Kellenberger, Stephen Miller, Mustafa Khan, David L. Gilday, Sheila Wietzman, Paul S. Babyn

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Abstract

Our objective was to compare fast spin-echo (FSE) short inversion time inversion recovery (STIR) whole-body MR imaging with standard procedures in staging children with lymphoma. Eight children (age range, 2-16 years) underwent multi-station FSE STIR whole-body MR at initial staging (n=5) or for restaging following completion of therapy (n=5). Whole-body MR and conventional staging procedures, including CT (n=10), gallium-67 scintigraphy (n=9), bone scintigraphy (n=3) and bone marrow biopsy (n=7) were retrospectively compared for detection of sites involved by lymphoma and for the assigned stage. FSE STIR whole-body MR detected more sites of possible lymphomatous involvement at initial staging (87/88) and at restaging (5/5) than did conventional imaging (74/88, 3/5). MR was more sensitive than conventional imaging in detecting bone marrow involvement at initial staging. Following treatment, however, residual and therapy-induced bone marrow signal abnormalities could not be differentiated from lymphomatous involvement. Detection of nodal and visceral involvement correlated well. Our results suggest that FSE STIR whole-body MR imaging is a sensitive technique for evaluating lymphomatous involvement of bone marrow as well as non-marrow sites. Larger prospective trials are needed to determine if FSE STIR whole-body MR can replace standard radiographic procedures for initial staging and contribute in the follow-up of lymphoma in children.

Original languageEnglish (US)
Pages (from-to)1829-1841
Number of pages13
JournalEuropean Radiology
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2004

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Whole Body Imaging
Lymphoma
Bone Marrow
Radionuclide Imaging
Gallium
Therapeutics
Biopsy
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kellenberger, C. J., Miller, S., Khan, M., Gilday, D. L., Wietzman, S., & Babyn, P. S. (2004). Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children. European Radiology, 14(10), 1829-1841. https://doi.org/10.1007/s00330-004-2432-z

Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children. / Kellenberger, Christian J.; Miller, Stephen; Khan, Mustafa; Gilday, David L.; Wietzman, Sheila; Babyn, Paul S.

In: European Radiology, Vol. 14, No. 10, 01.10.2004, p. 1829-1841.

Research output: Contribution to journalArticle

Kellenberger, CJ, Miller, S, Khan, M, Gilday, DL, Wietzman, S & Babyn, PS 2004, 'Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children', European Radiology, vol. 14, no. 10, pp. 1829-1841. https://doi.org/10.1007/s00330-004-2432-z
Kellenberger, Christian J. ; Miller, Stephen ; Khan, Mustafa ; Gilday, David L. ; Wietzman, Sheila ; Babyn, Paul S. / Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children. In: European Radiology. 2004 ; Vol. 14, No. 10. pp. 1829-1841.
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